Structure of PDB 6olz Chain BS Binding Site BS01

Receptor Information

>6olz Chain BS (length=139) Species: 9606 (Homo sapiens)

VIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLT
KRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGL
DNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR

Ligand information

>6olz Chain A2 (length=3643)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggggcgcgggacaugug
gcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccu
ucugaucgaggcccagcccguggacggugugaggccgguagcggcccccg
gcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcggguccggccgugucggcggcccggc
ggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcg
accggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccg
ggacggcugggaaggcccggcggggaagguggcucggggcccccgagugu
uacagcccccccggcagcagcacucgccgaaucccggggccgagggaagc
gagacgucgccgcgcucuccccccugggggggccgggccaccccucccac
ggcgcgaccgcucucccagggggcggggcggacuguccccagugcgcccc
gggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacg
gcggagcgagcgcacggggucggcggcgacgucggcuacccacccgaccc
gucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuc
gcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccg
gccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccgg
cccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuag
gacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaac
ucugguggagguccguagcgguccugacgugcaaaucggucguccgaccu
ggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccucc
gaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgg
uaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucu
caaacuuuaaauggguaagaagcccggcucgcuggcguggagccggggug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcgucgagaguggacgggagcggcggcccgcccgcggacgcuacgccgcg
acgaguaggagggccgcugcggugagccuugaagccuagggcgcgggccc
ggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaa
acgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcagu
ugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagg
gacgggcgauggccuccguugcccucggccgaucgaaagggagucggguu
cagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagu
gcgguaacgcgaccgaucccggagaagccggcgggagccccggggagagu
ucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgag
agaggggcccgugccuuggaaagcgucgcgguuccggcggcguccgguga
gcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgcc
gggccguacccauauccgcagcaggucuccaaggugaacagccucuggca
uguuggaacaauguagguaagggaagucggcaagccggauccguaacuuc
gggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcgg
accaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgc
ggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaag
ugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucu
cuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugg
augaacgagauucccacugucccuaccuacuauccagcgaaaccacagcc
aagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcu
ugacucuagucuggcacggugaagagacaugauagaauaagugggaggcc
cgggccgccggugaaauaccacuacucugaucguuuuuucacugacccgg
ugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcc
cgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuu
gacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgag
cucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuu
gaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgau
ccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagc
guuggauuguucacccacuaauagggaacgugagcuggguuuagaccguc
gugagacagguuaguuuuacccuacugaugauguguuguugccaugguaa
uccugcucaguacgagaggaaccgcagguucagacauuugguguaugugc
uuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacug
aacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccg
cggagccucgguuggccucggauagccgguccgggguccggugcggagug
cccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucg
cccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucgua
gacgaccugcuucugggucgggguuucguacguagcagagcagcucccuc
gcugcgaucuauugaaagucagcccucgacacaaggguuuguc

.........................<<<<<<<....<......>.....>
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.......>.>..................................>>>>.>
.>....>....>>..>>.>.......<<<<<<<........>>>>>>>..
...(((((..<<<<<<)))))..]]]........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<<........
..<<.<.<<<<......<<..<.<<.........<<...<<.<....<<<
<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>>>>...>>.....
.....>.>>..>.>.....>>>>.>.>>.....<<<<<<<..<<<<<<<<
<..<<<........<<.<<<.<<.<......<<<<<<<...>>>>>>>..
......>>>.>>>>>...........>>>....>>>>>>>>>........
...........<<<....<<<<<<..>>>>>>....<<<.<<<..<<...
<.<..<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>
>>>>>>.>...>>....>>....>>>.>>>........<<<<<.>.>>>>
..........>>>.......>>.>>>>>....>>>...>>>>>>>>..<<
<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.
.......>>>>.....>>>...<<....>>...<<<<<<<......>>>>
>>>..<<<<<..<<<...<.....[[...[...>...>>>...>>>>>.<
<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>
..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>
>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>
>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<
....<.<<<....>>>(><<.<<<<<<<........<<<.<<<<<<<<<.
..<<<....<<<....<<<...<<<<<.........>>>>>.>>>....>
>>..>.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>...
.>>>>>>>>>>>>..>>).<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.......<<<<<.<<.............
........>>.........<........>...>>>>>...>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
............]...]]...........................>.>>>
>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>
>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<
<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........
<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<..
......>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..
<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<.
.{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>...
..>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...
>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>
>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>.
...<<<<.....<<<<<<<.<<...............<<<<<........
.......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>.......
.....<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<..
...>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<
<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>
>........<...........<<<<<.......>>>>>.....>.....>
>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<
<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[
..<<<<<.<<<<<<<<<.<<<<<<<<<.<<.........<<<<<..<<<<
..>>>>............>>>>>......>>..>>>>>>>>>...<<<<<
.....<<<<........<<<...>>>...................<<<<<
<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>..
.<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......
.((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]
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.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.
>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<
....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<.<
<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<.
..........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<
.<<..<<<...................<.<<<>>>.>.............
.....<<<..<<<<.....<<<.<<<<<<<......>>>>>>>>>>....
>>>>..>>>..............>>>...>>>>>>>>><<<<<.<.....
........>.....<.<<<<<<<.<<.....<<<<.<..<<<<<......
>>>>>..>>>>>....>>....>>>>.>>>.>...>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): E112 K115 K116 R118
• Binding residue (residue number reindexed from 1): E109 K112 K113 R115

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6olz, PDBe:6olz, PDBj:6olz
• PDBsum: 6olz
• PubMed: 31160784
• UniProt: P62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)