Structure of PDB 4v6g Chain BS Binding Site BS01

Receptor Information

>4v6g Chain BS (length=113) Species: 300852 (Thermus thermophilus HB8)

MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKV
LESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRT
SHITVILGEKHGK

Ligand information

>4v6g Chain BA (length=2885)

agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga
cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc
uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc
uugcgcggggggaaccuggggaacugaaacaucucaguacccagaggaga
ggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagcc
uaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaa
uccccagccuagccgaagcuguugggaagcagcgccagagagggugaaag
ccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgu
gguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaag
uacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaag
aaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagca
gucacggccccgcaagggguuguggcgugccuauugaagcaugagccggc
gacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaa
accgaguccgaacagggcgcaaacgcgaaaaguccgcggccguggacccg
aaaccgggcgagcuagcccuggccagggugaagcuggggugagacccagu
ggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcua
ggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaauga
cuuuagggucagccucaggcgcugacuggggccuguagagcacugauagg
gcuagggggcccaccagccuaccaaacccugucaaacuccgaaggguccc
agguggagccugggagugagggcgcgagcgauaacguccgcguccgagcg
cgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugg
uaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagc
caucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaacaagcucugcguggugg
ggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagc
cucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggc
gggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucug
caaguuggccccguaacuucgggagaaggggugcucccuggggugaugag
ccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacac
agcucucugcgaacucguaagaggagguauagggagcgacgcuugcccgg
ugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggug
aacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggc
gagggacccggugaaauugaacuggccgugaagaugcggccuacccgugg
caggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuu
ggucgcgccugcguaggauaggugggagccugugaacccccgccuccggg
ugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaa
cccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacgga
aauccgccggagagcgcaaggguagaagggggccugacugcgaggccugc
aagccgagcaggggcgaaagccgggccuagugaaccgguggucccgugug
gaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcuga
ucucccccgagcguccacagcggcggggagguuuggcaccucgaugucgg
cucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcc
cauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggu
cucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacg
agaggaccggaagggacgcaccucugguuucccagcugucccuccagggg
cauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaa
gcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaag
gacccgggaagaccacccgguggaugggccggggguguaagcgccgcgag
gcguugagccgaccggucccaaucguccgaggucu

<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<
<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>
>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<
..>>>>>>.>>....<<<<<.....<<....>>......>>>>>......
.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<
....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...
<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)
)>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<
<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....
..>>.>>>>>>.>>...............<<....>>....>>.......
..<<<<....>>>>..................>>>>>>>>>>>.......
<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<
....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<...
.>>..<<<<.....>>>>.....<..>....>>>>>>>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<
<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>
>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....
<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.......
....<<.<<<<<<<<<<........<<<<<.<<...<<<<.......>>>
>...>>.........<<......>>...>>>>>....>>>>>>>>>>>>.
.........)))......>>>>>>.>>>...>>>>>>><<<<<<<<....
.>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<...
.>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....
<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<
<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>
<...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>
>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<.......
.<.....<<<<<...............>>>>><<<<<<<<<<<<.....>
>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>.
.<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<
<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>.
.>>>>><<<<<<.......>>>>>>........<...........<<<<<
<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>
>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...
<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..)))
)..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<
.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.....>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>
>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>
>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<
<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>
>>>>...>>>..>>>>>.>>>...>>>>....>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v6g Structural aspects of messenger RNA reading frame maintenance by the ribosome.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): I6 A7 R8 Y9 R11 S13 R15 K16 R18 K41 R42 Y45 K49 S53 A56 N57 N60 N61 D77 E78 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102
• Binding residue (residue number reindexed from 1): I6 A7 R8 Y9 R11 S13 R15 K16 R18 K41 R42 Y45 K49 S53 A56 N57 N60 N61 D77 E78 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6g, PDBe:4v6g, PDBj:4v6g
• PDBsum: 4v6g
• PubMed: 20400952
• UniProt: Q5SHP3|RL22_THET8 Large ribosomal subunit protein uL22 (Gene Name=rplV)