Structure of PDB 6hix Chain BQ Binding Site BS01

Receptor Information
>6hix Chain BQ (length=216) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQYFVPYERDEVNPVVFMDVTVEGDALGRVSVELFHDIVPKTTENFRSLC
TGERGYSQCPLFYKGIPFHRVIPGFIVQGGDILLKDGRGNVSVFGFPFPD
ESFEGKAGKHLRGTVAMAHSAPNQNGSQFFFNLARNDHLDGKFVVCGQVI
DGWEVVDRVAVLSGSSCGTPVSRAWITECGQSSGDKLEDTERALSGERAL
HTMPGKEVLDILSPRY
Ligand information
>6hix Chain AA (length=591) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB6hix Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution3.39 Å
Binding residue
(original residue number in PDB)		Y71 S72 Q73 P75 H216 T217
Binding residue
(residue number reindexed from 1)		Y56 S57 Q58 P60 H201 T202
Enzymatic activity
Catalytic site (original residue number in PDB) R85 F90 Q93 H134 F145 L154 F158
Catalytic site (residue number reindexed from 1) R70 F75 Q78 H119 F130 L139 F143
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016018 cyclosporin A binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005762 mitochondrial large ribosomal subunit
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hix, PDBe:6hix, PDBj:6hix
PDBsum6hix
PubMed30213880
UniProtQ57WF8

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