Structure of PDB 8cq7 Chain BP Binding Site BS01

Receptor Information
>8cq7 Chain BP (length=102) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSVKKFVVDVAAPVENDVFDQESYVKYLVEHVKVDGIVGNLGNDISITAE
SDNKVVVVVSGNGSFSGKYLKYLTKKYLKKNQIRDWIRFVSVKQNQYKLQ
FY
Ligand information
>8cq7 Chain AS (length=3222) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaaug
gcggaggaauguggcacggcuucugcuguguguuauagccucugacgaua
cugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaa
ugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucua
ugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaagg
ugggggcccauuagggugcaccaucgaccgauccugauguguucggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaauagggugaagccagaggaaacucugguggaggcucguagcgguucu
gacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucg
aaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaag
cucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguug
aaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguu
gcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagug
ccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagac
agccggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugc
uacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcag
gcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggcc
ucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuuga
agacugaaguggggaaagguuccaugucaacagcaguuggacauggguua
gucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuuca
ggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauaugg
auucuucacggcaacguaacugaauguggagacgucggcgugagcccugg
gaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuau
ccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcgucc
ggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucau
gccaagucguacucauaaccgcagcaggucuccaagguuaacagccucua
guugauagaauaauguagauaagggaagucggcaaaauagauccguaacu
ucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugg
uacggacaaggggaaucugacugucuaauuaaaacauagcauugugaugg
ucagaaagugauguugacacaaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggauuaacgagauucccacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguu
gagcuugacucuaguuugacauugugaaaagacauggaggguguagaaua
agugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuua
cuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaa
gcccucugggcgauccggguugaagacauugucagguggggaguuuggcu
ggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacuca
uggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauu
uugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuu
uagucccucggaauuugaggcuagaggugccagaaaaguuaccacaggga
uaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauuc
uucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguug
gauuguucacccacuaauagggaacgugagcuggguuuagaccgucguga
gacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaa
cuuaguacgagaggaaccguucauucagauaauugguuuuugcggcuguc
ugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgc
cucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauu
uuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcugg
caacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaa
ugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaac
ggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauu
aagcucuuguugucugauuugu
.......................<<<<<<.....<......>......>>
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....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
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>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<...<<<<
......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.
<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.
>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....
>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<
<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<
<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>
>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<
<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.
<<........>>>>.>>>....>>>>>>>>>...<<.......>>.....
.>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<
<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<..
.....>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<
.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(
((.....<<<<<<.....<<..........<<<.<<<<<<<<<<......
.<<<<<.<<<...<<.........>>...>>>.........<<......>
>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>
.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>
>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>
>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<
<<.....<<<....>>>......{<<<<<<...<<<<.<<<<<<<.<<<<
<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....
>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>
>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>
>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<......
.........>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......
>>>>>>........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>.
...<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<
<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<..........
.......<......>....................>>.>>.>>>>>>>>>
>...<<<<<.....<<<<..<<<<<......>>>>>..........}...
<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<
.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...
<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<
<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<
<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>..
.....<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>
.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<
<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....
>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<
<.................>>>>>.><<<<<...<<<<....<<<<<<<<<
<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<......
.....>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.
......<<..........<<<<....>>>>......>>.......<<<<<
<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.........
.......>>>.>>>>>>..<<<<<<<.............>>....<<<<<
<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>.
...>>>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.2 Å
Binding residue
(original residue number in PDB)
F15 K42 G45 F74 S75 G76 K77 Y78 K80 Y81 K85 K88 R97 V99 S100 Q103 N104 Y106 Q109
Binding residue
(residue number reindexed from 1)
F6 K33 G36 F65 S66 G67 K68 Y69 K71 Y72 K76 K79 R88 V90 S91 Q94 N95 Y97 Q100
External links
PDB RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
PDBsum8cq7
PubMed
UniProtA0A1D8PM41|RL22B_CANAL Large ribosomal subunit protein eL22 (Gene Name=RPL22B)

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