Structure of PDB 5aj0 Chain BP Binding Site BS01

Receptor Information
>5aj0 Chain BP (length=120) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLR
KAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEM
IGHYLGEFSITYKPVKHGRP
Ligand information
>5aj0 Chain B1 (length=1708) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucua
gagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgu
gcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccu
cgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucug
cccuaucaacuuucgaugguagucgccgugccuaccauggugaccacggg
ugacggggaaucaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgg
ggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaa
uuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaa
gucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaa
guugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugc
cucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
ccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguu
cuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgg
gggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaaga
cggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacg
aaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaa
acgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucu
uagagggacaaguggcguucagccacccgagauugagcaauaacaggucu
gugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcuc
agcgugugccuacccuacgccggcaggcgcggguaacccguugaacccca
uucgugauggggaucggggauugcaauuauuccccaugaacgaggaauuc
ccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuugu
acacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucgg
aucggccccgccguggcggagcgcugagaagacggucgaacuugacuauc
uagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaag
gaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[[[....<<.....<<.<<<.....>>>
.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>
[[..(((((.....<<<<<<<<.<<.>>....<......>..)))))...
...]]...<<<<..<<<......>>>.>>>>.]].]]]...}}....]]]
.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.
>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>
>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>
>>>......<<..<...........>..>>.........<<<<<((....
..<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]..
..........{{.......{{...[[[.......<<<.....>>>....<
.<..<....>>.>....<<<<<.<.......<<...<.......>.<<<<
.......>>>>...>>......>.>>>..>>...........[...((((
((......>>>>>>>>.))))))...]............<<<<<<..<..
.<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..
>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}...
...<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.....
.....<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..
>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>
>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<..
......<<.<<<........>>>.>>......>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>
>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>..
...>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<...
.....<.......<<<.<<<<....>>>>.>>>....>.........>>>
.>>......<.....<<<<<..........>>>>>.....>.....>>>>
>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<..
.<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>
>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5aj0 Structural Snapshots of Actively Translating Human Ribosomes
Resolution3.5 Å
Binding residue
(original residue number in PDB)		S38 A39 R40 R42 R43 R44 R47 R51 H54 S55 K77 H79 D82 Y97 G99 K100 Y115 I121 T122 Y123 K124 V126 H128 R130
Binding residue
(residue number reindexed from 1)		S27 A28 R29 R31 R32 R33 R36 R40 H43 S44 K66 H68 D71 Y86 G88 K89 Y104 I110 T111 Y112 K113 V115 H117 R119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000056 ribosomal small subunit export from nucleus
GO:0001649 osteoblast differentiation
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0097421 liver regeneration
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum5aj0
PubMed25957688
UniProtP62841|RS15_HUMAN Small ribosomal subunit protein uS19 (Gene Name=RPS15)

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