Structure of PDB 8ova Chain BO Binding Site BS01

Receptor Information
>8ova Chain BO (length=221) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLPSRRSLNRSSRKGFKKHRPDIIVIDLKDHVLGRAAAIVAKQLLLGKKI
TVVRCEKLTIAGSEIRNKIKYLQFLRKRKLSNPKLGPFHHRSPSDVFIRT
VRSMLPRYTKRGQRALRQLVAYEGVPVNVVRTGGRVVIPKAQRHNCYRNE
RRFTVLGNMCKHVGWKYSDVVEKLEAARIEKSGRHHKKMEKVRVAWKNAR
KEALKKMPQKNVEVLKKFGLA
Ligand information
>8ova Chain BA (length=1604) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauuacaacccuucaugugaguauugagccaaagaaggugucagcc
cauuacagccacggagccuacgcgccuccucaagagaguagcacuguuug
ggaaugcagugucaagccggcagguauuugucugccaagguuaaauauag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagu
acuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugg
aaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuc
cggggcuaacauccggugggucacugugcggguuucgaggucauggggug
cgugagugggcggaauaaagggucgguguguuguguucuuccuccuuccc
uguccgugcgucucgacgcuggcgauggaaauggggugcccccacccguc
uugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauugu
gacaacucuuuucucguacugaaagggaggugugauacacccguggcgug
cgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagu
gugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaag
cccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgc
ucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagc
ugguucacgucgaaguuucccucaggauagcuggugcuugucaagaagua
uugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaug
ugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggc
accaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccg
cuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaa
aaggguguugguggauauccaccggccccgaaaauggaugacgcuuaagc
cccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggu
gagaaaguguagcccucccgauguagacguggcgugggggugaggacgaa
gccgauggcgcgagccucggauggacccgccucuagugcagaucuugguu
ggcguagcaaagaucuaacggaauauuuuuaaaugcaacguuggauacug
gagcggggaaggauuucgugccaacggcacucguacacgaguuguucggu
cacugagcacaacguuacaccguuuuguuaggaaagugaaggugcucuga
aaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugug
ggac
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>........<<........>>......>>>.<<.......((.....>>)
)......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<...
.....>>>>>>>......<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<
<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>....
..........<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>
>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<.
.......>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.....
....>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<.
.<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>
.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>
.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...
<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>
>>>>>...<..<....<<.<......>>>....>..>......>>..>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>
>..<<<<<<<...<<<(((......<<.<<<<........<.........
..<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>
>>>>...........>>>...>>>>>>><<<<.<<<<<...........>
>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........
<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>.
.............<<<<<<<..................>>>>>>>.....
...............<<<<<....<<.....>>..>>>>>.....<....
......<<.<<<<<......>>>>...............<<<...>>>..
....>.>>..........<<<<.........>>....>>.>.........
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		G35 R36 K43 I66 R67 I70 R77 K78 R79 K80 M105 P107 K111 K141 Y148 R149 R152
Binding residue
(residue number reindexed from 1)		G34 R35 K42 I65 R66 I69 R76 K77 R78 K79 M104 P106 K110 K140 Y147 R148 R151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ585J5

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