Structure of PDB 8oeq Chain BO Binding Site BS01

Receptor Information
>8oeq Chain BO (length=159) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKSRGYRSGTRYAFQRDFKKHGAIPLSTYLKVYKVGDIVDIKANGSIQKG
MPHKYYHGKTGIVYNVTKSSVGVIINKVVGNRYIEKRVNLRVEHVKHSAC
RQEFLNRVKSNAAKKREAKANGETVYLKRQAAKPRGSRIISTEGNIPQTL
APVAYETFI
Ligand information
>8oeq Chain AS (length=3199) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauugcggu
uuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaaugu
ggcacggcuucugcuguguguuauagccucugacgauacugccagccuag
accgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaaguc
gcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuug
gguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauu
agggugcaccaucgaccgauccugauguguucggauggauuugaguaaga
gcauagcuguugggacccgaaagauggugaacuaugccugaauaggguga
agccagaggaaacucugguggaggcucguagcgguucugacgugcaaauc
gaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuagua
gcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguu
uuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaa
cuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaac
guggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaa
cuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacg
cucaucagacaccacaaaagguguuaguucaucuagacagccggacggug
gccgcuaaggaguguguaaacucaccggccgaaugaacuagcccugaaaa
uggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuug
acgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcug
uaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaa
uauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaa
cagcaguuggacauggguuagucgauccuaagagauggggaagcuccguu
ucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaa
auuccggaacuuggauauggauucuucacggcaacguaacugaaugugga
gacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuua
ucacccuggaauugguuuauccggagauggggucuuauggcuggaagagc
gcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaaucca
caggaaggaauaguuuucaugccaagucguacucauaaccgcagcagguc
uccaagguuaacagccucuaguugauagaauaauguagauaagggaaguc
ggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucggg
cacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacug
ucuaauuaaaacauagcauugugauggucagaaagugauguugacacaau
gugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaag
cgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugc
cucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacu
gucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggca
gaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauu
gugaaaagacauggaggguguagaauaagugggagcuucggcgccgguga
aauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcugg
aggucaaacuccacguucuagcauuaagcccucugggcgauccggguuga
agacauugucagguggggaguuuggcuggggcggcacaucuguuaaacga
uaacgcagguguccuaagggggacucauggagaacagaaaucuccaguag
aacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaa
ccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcua
gaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagc
guucauagcgacauugcuuuuugauucuucgaugucggcucuuccuauca
uaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggga
acgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacug
augaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguuca
uucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcu
accaucugcuggauuauggcugaacgccucuaagucagaauccaugcuag
aacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuu
uuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaagg
cuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaau
ccuuugcauacgacuuagauguacaacggaguauuguaagcaguagagua
gccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu
.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<.........
...>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<.....
.<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>
>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>
..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<
<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<...
.>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....
>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<
<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>
>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>
>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>
.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<
<.....<<.....]....<<<.<<<<<<<<<<.......<<<<<.<<<..
.>>>.........<<....>>...>>>>>...>>>>>>>>>>>>>.....
.....))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.......
..>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<.
...>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<...
..<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...
<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>...
.......<<<<<<....>>>>>>......>>....>>...<<<<<.....
...>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<
...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<..
..<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<
<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>
>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>
>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<......
...<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..
.........>>>>>..>>>>>>.>>............<<<<<<<<<..<<
<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>
>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>
>>.>>>>..>>>>><<<<<<.......>>>>>>........<........
...<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>
..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>..
..<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..
<<<<<<<<<<<<...<<.................<......>........
............>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<<
<<......>>>>>..............<<<<...>>>>..>>>>..>>>>
>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>
.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>
>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<
.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.
<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>
..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>
>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>
.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>
>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.
...>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<<.
...>>>>......>>.......<<<<<<...<<<<<<<..<<<......>
>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<
<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<
<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G2 K3 S4 R5 G6 Y7 R8 S9 G10 R12 Y13 A14 Q16 R17 F19 H22 G23 K35 D41 G46 S47 Q49 K50 G51 H54 K55 Y57 H58 G59 K60 T61 T68 K69 S70 S71 K78 V80 R83 K87 R88 N90 R92 A100 R102 E104 F105 V109 K116 K120 Y127 L128 K129 R130
Binding residue
(residue number reindexed from 1)		G1 K2 S3 R4 G5 Y6 R7 S8 G9 R11 Y12 A13 Q15 R16 F18 H21 G22 K34 D40 G45 S46 Q48 K49 G50 H53 K54 Y56 H57 G58 K59 T60 T67 K68 S69 S70 K77 V79 R82 K86 R87 N89 R91 A99 R101 E103 F104 V108 K115 K119 Y126 L127 K128 R129
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