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Structure of PDB 8oiq Chain BN Binding Site BS01

Receptor Information

>8oiq Chain BN (length=250) Species: 9823 (Sus scrofa)

PPVLRKCELPVPAHRRPVQAWIESLRGYEQERVGLTELHPDVFSTAPRLD
ILHQVAIWQKNFKRISYAKTKTRAEVRGGGRKPWVQKGSGRARHGSIRSP
IWRGGGVAHGPRGPTSYYYMLPMKVRVQGLKVALTVKLAQDDLHIVDSLE
LPTADPQYLIELARYRRWGDSVLLVDLEHEDMPQNVVAATSGLKTFNLVP
AVGLNVHSMLKHQTLVLTLPTVAFLEEKLLWHNSRYTPLYPFRLPYCDFP

Ligand information

>8oiq Chain B8 (length=1571)

accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaa
aauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuaucc
ugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaa
aguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaa
ccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccaga
cgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaa
uagugagaagacuuguagguagaggugaaaagccuaacgagccuggugau
agcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaa
aacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcu
uuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuacc
auaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaaca
aauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauac
cggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaa
gaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacuga
uaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuaca
uuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaa
ggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucua
gcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacgg
ccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaau
aaggacuuguaugaauggccacacgaggguuuuacugucucuuacuucca
aucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagac
gagaagacccuauggagcuuuaauuaacuauuccaaaaguuaaacaacuc
aaccacaaagggauaaaacauaacuuaacauggacuagcaauuucgguug
gggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaa
accagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaa
cggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccu
aucgacaauaggguuuacgaccucgauguuggaucaggacacccaaaugg
ugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacguga
ucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauu
ucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgu
cucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaau
ccagcccuagaacagggcaca

<<.<......<<<<....................................
...<......>.................<<.....>>.............
.>>.>>.............<<....>>...................>...
.>>...........<<<.......>>>...<.<........>.>..<<<<
<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.
<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>
>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>
..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<
<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>
>>>>>>>...<<......>>....<<<<.<<<..................
......<<<.........>>>............<<<......>>>.....
...................................>>>>>>>........
>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..
<<<....>>><<<<.<<<<........<<<<<....<<....>>..>>>>
>......<<<..<<<<<<<.................>>>>>>>.......
>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<
<.........<.....<<<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>
><<<<<<......>>>>>>........<...........<<<<<......
.>>>>>.....>....>>>.>..>>.>>>>>>...>..>>.>>>>>>>.>
>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.
<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<........
....................>>>>>>....>>>>.>>>.>>>>..<<<<.
....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<..
....>>>...>>.........>>>>..........<<<....>>>.....
.......>>>>..>>>>>>.......<<<..<.<<<<<<...<<......
.>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<
<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...
>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<
<<<<.................>>>>>>><<<<<...<.........>.>>
>>>.<<<...<<<<.<............>..>>>>...>>>.>>......
...<<<<.......>>>>...

Receptor-Ligand Complex Structure

Structure summary

Jmol._Canvas2D (Jmol) "jmolApplet0"[x]

Jmol._Canvas2D (Jmol) "jmolApplet1"[x]

• PDB: 8oiq Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): R92 H97 I101 K104 N105 R108 Y111 K113 K115 R117 A118 R121 R125 K126 Q130 K131 G132 R135 A136 R137 H138 G139 R142 P144 I145 W146 R147 V151 H153 P155 Y161 Y163 P166 M167 K168 V169 R170 K255 T281 P282 P285
• Binding residue (residue number reindexed from 1): R48 H53 I57 K60 N61 R64 Y67 K69 K71 R73 A74 R77 R81 K82 Q86 K87 G88 R91 A92 R93 H94 G95 R98 P100 I101 W102 R103 V107 H109 P111 Y117 Y119 P122 M123 K124 V125 R126 K211 T237 P238 P241

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8oiq, PDBe:8oiq, PDBj:8oiq
• PDBsum: 8oiq
• PubMed: 37141370
• UniProt: A0A287B9C4

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