Structure of PDB 8c3a Chain BN Binding Site BS01

Receptor Information

>8c3a Chain BN (length=170) Species: 5476 (Candida albicans)

RLNEYQVIGRNLPTESVPEPKLFRMRIFAPNTVVAKSRYWYFLQKLHKVK
KASGEIVSVNIISEAKPTKVKTFGIWLRYESRSGIHNMYKEYRDVTRVGA
VETMYQDLAARHRARFRSIHILKVVELEKTDDVKRQYVKQFLTKDLKFPL
PHRVQKSKKLFQATAPTTFY

Ligand information

>8c3a Chain AS (length=3229)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaaug
gcggaggaauguggcacggcuucugcuguguguuauagccucugacgaua
cugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaa
ugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucua
ugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaagg
ugggggcccauuagggugcaccaucgaccgauccugauguguucggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaauagggugaagccagaggaaacucugguggaggcucguagcgguucu
gacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucg
aaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaag
cucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguug
aaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguu
gcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagug
ccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagac
agccggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugc
uacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcag
gcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggcc
ucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuuga
agacugaaguggggaaagguuccaugucaacagcaguuggacauggguua
gucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuuca
ggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauaugg
auucuucacggcaacguaacugaauguggagacgucggcgugagcccugg
gaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuau
ccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcgucc
ggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucau
gccaagucguacucauaaccgcagcaggucuccaagguuaacagccucua
guugauagaauaauguagauaagggaagucggcaaaauagauccguaacu
ucgggauaaggauuggcucuaaggaucgggcacguuuaacgaucaacuua
gaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauu
gugauggucagaaagugauguugacacaaugugauuucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagu
aacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugac
gcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagc
gaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaaga
cccuguugagcuugacucuaguuugacauugugaaaagacauggagggug
uagaauaagugggagcuucggcgccggugaaauaccacuaccucuauagu
uuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucua
gcauuaagcccucugggcgauccggguugaagacauugucagguggggag
uuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaaggg
ggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccc
cuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuauc
gauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuacc
acagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuu
uugauucuucgaugucggcucuuccuaucauaccgaagcagaauucggua
agcguuggauuguucacccacuaauagggaacgugagcuggguuuagacc
gucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauagu
aauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugc
ggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggc
ugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccu
gcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagc
aggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcgg
auagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagau
guacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugc
ugagauuaagcucuuguugucugauuugu

.......................<<<<<<.....<......>......>>
>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>....>..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<...<<<<
......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.
<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.
>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....
>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<
<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<
<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>
>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<
<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.
<<........>>>>.>>>....>>>>>>>>>...<<.......>>.....
.>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<
<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<..
.....>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<
.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(
((.....<<<<<<.....<<..........<<<.<<<<<<<<<<......
.<<<<<.<<<...<<.........>>...>>>.........<<......>
>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>
.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>
>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>
>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<
<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<
<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....
>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>
>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>
>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<......
.........>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>
>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<
....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<
.......>>>>>>........<...........<<<<<.......>>>>>
.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>
....>>....<<<<<........>>>>>....<<<<<..<<<.<<.....
.<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<...
..............<......>...................>>..>>.>>
>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>.......
...}}..<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>
>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<
<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>
>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))...
...<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>
>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>..
.>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>
...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<
<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<
...<<<<<.................>>>>>..<<<<<...<<<<....<<
<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<
<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<
<<.<<<.......<<..........<<<<....>>>>......>>.....
..<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..
..............>>>.>>>>>>..<<<<<<<.............>>..
..<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>
...>>>....>>>>.>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c3a New crystal system to promote screening for new eukaryotic inhibitors
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): N62 S65 E66 K68 P69 K71 S83 R84 S85 H88 N89 M90 Y91 K92 Q108 A111 A112 R113 H114 R115 R117 T132 R137 Y139 L144 T145 K146 H154 R155 Q157 K158 S159 K161 Q164 A165 A167 P168 T169 T170 F171
• Binding residue (residue number reindexed from 1): N60 S63 E64 K66 P67 K69 S81 R82 S83 H86 N87 M88 Y89 K90 Q106 A109 A110 R111 H112 R113 R115 T130 R135 Y137 L142 T143 K144 H152 R153 Q155 K156 S157 K159 Q162 A163 A165 P166 T167 T168 F169

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
• PDBsum: 8c3a
• UniProt: A0A8H6BZJ3