Structure of PDB 8c3a Chain BL Binding Site BS01

Receptor Information

>8c3a Chain BL (length=185) Species: 5476 (Candida albicans)

GRDHTSKQHVRSGHRTAPKSDNVYLQLLVKLYSFLARRTDAPFNKVILKS
LFLSKINRPPVSVSRISRALKQKGAAEKTIVVVGTVTDDNRLLEFPKATI
AALRFTAGAKDRILKNGGEAITLDQLALRAPKGQNTLIVRGPRNSREAVR
HFGFGPHKGKAPRILSKGRKFERARGRRRSRGFKV

Ligand information

>8c3a Chain AS (length=3229)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaaug
gcggaggaauguggcacggcuucugcuguguguuauagccucugacgaua
cugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaa
ugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucua
ugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaagg
ugggggcccauuagggugcaccaucgaccgauccugauguguucggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaauagggugaagccagaggaaacucugguggaggcucguagcgguucu
gacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucg
aaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaag
cucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguug
aaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguu
gcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagug
ccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagac
agccggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugc
uacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcag
gcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggcc
ucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuuga
agacugaaguggggaaagguuccaugucaacagcaguuggacauggguua
gucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuuca
ggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauaugg
auucuucacggcaacguaacugaauguggagacgucggcgugagcccugg
gaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuau
ccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcgucc
ggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucau
gccaagucguacucauaaccgcagcaggucuccaagguuaacagccucua
guugauagaauaauguagauaagggaagucggcaaaauagauccguaacu
ucgggauaaggauuggcucuaaggaucgggcacguuuaacgaucaacuua
gaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauu
gugauggucagaaagugauguugacacaaugugauuucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagu
aacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugac
gcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagc
gaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaaga
cccuguugagcuugacucuaguuugacauugugaaaagacauggagggug
uagaauaagugggagcuucggcgccggugaaauaccacuaccucuauagu
uuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucua
gcauuaagcccucugggcgauccggguugaagacauugucagguggggag
uuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaaggg
ggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccc
cuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuauc
gauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuacc
acagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuu
uugauucuucgaugucggcucuuccuaucauaccgaagcagaauucggua
agcguuggauuguucacccacuaauagggaacgugagcuggguuuagacc
gucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauagu
aauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugc
ggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggc
ugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccu
gcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagc
aggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcgg
auagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagau
guacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugc
ugagauuaagcucuuguugucugauuugu

.......................<<<<<<.....<......>......>>
>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>....>..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<...<<<<
......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.
<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.
>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....
>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<
<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<
<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>
>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<
<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.
<<........>>>>.>>>....>>>>>>>>>...<<.......>>.....
.>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<
<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<..
.....>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<
.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(
((.....<<<<<<.....<<..........<<<.<<<<<<<<<<......
.<<<<<.<<<...<<.........>>...>>>.........<<......>
>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>
.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>
>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>
>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<
<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<
<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....
>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>
>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>
>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<......
.........>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>
>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<
....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<
.......>>>>>>........<...........<<<<<.......>>>>>
.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>
....>>....<<<<<........>>>>>....<<<<<..<<<.<<.....
.<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<...
..............<......>...................>>..>>.>>
>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>.......
...}}..<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>
>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<
<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>
>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))...
...<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>
>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>..
.>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>
...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<
<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<
...<<<<<.................>>>>>..<<<<<...<<<<....<<
<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<
<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<
<<.<<<.......<<..........<<<<....>>>>......>>.....
..<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..
..............>>>.>>>>>>..<<<<<<<.............>>..
..<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>
...>>>....>>>>.>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c3a New crystal system to promote screening for new eukaryotic inhibitors
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): G2 R3 H5 Q9 H10 V11 R12 S13 G14 H15 R16 K20 S21 Q27 K31 F35 R38 R39 P43 F44 L54 S55 K56 I57 N58 P61 S65 R66 R69 K72 Q73 K79 T86 T88 D89 D90 N91 R92 R105 T107 A108 Q135 N136 T137 I139 R141 R144 N145 S146 R147 E148 R151 F153 P157 H158 K161 A162 P163 R164 S167 K168 R170 K171 F172 R174 R179 S181 R182 F184 K185
• Binding residue (residue number reindexed from 1): G1 R2 H4 Q8 H9 V10 R11 S12 G13 H14 R15 K19 S20 Q26 K30 F34 R37 R38 P42 F43 L53 S54 K55 I56 N57 P60 S64 R65 R68 K71 Q72 K78 T85 T87 D88 D89 N90 R91 R104 T106 A107 Q134 N135 T136 I138 R140 R143 N144 S145 R146 E147 R150 F152 P156 H157 K160 A161 P162 R163 S166 K167 R169 K170 F171 R173 R178 S180 R181 F183 K184

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
• PDBsum: 8c3a
• UniProt: A0A8H6C4Y1