Structure of PDB 8cre Chain BJ Binding Site BS01

Receptor Information
>8cre Chain BJ (length=199) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSFEKVVVIDGKGHLLGRLASIVSKQILNGQKVVVVRCEELNISGEFFRN
KLKYHDYLRKATRYNKKKGPFHFRAPSRILYKAIRGMIPHKTARGKAALE
RLKVFEGVPPPYDKKKRVVVPQALRVLRLKPGRKYTTVGKLSSAVGWKYE
SVVEKLEEKRKVQSAEYYAKKKALTKKLNAAKASTAESEAAQKLAAFGY
Ligand information
>8cre Chain AS (length=3229) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaaug
gcggaggaauguggcacggcuucugcuguguguuauagccucugacgaua
cugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaa
ugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucua
ugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaagg
ugggggcccauuagggugcaccaucgaccgauccugauguguucggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaauagggugaagccagaggaaacucugguggaggcucguagcgguucu
gacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucg
aaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaag
cucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguug
aaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguu
gcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagug
ccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagac
agccggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugc
uacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcag
gcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggcc
ucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuuga
agacugaaguggggaaagguuccaugucaacagcaguuggacauggguua
gucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuuca
ggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauaugg
auucuucacggcaacguaacugaauguggagacgucggcgugagcccugg
gaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuau
ccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcgucc
ggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucau
gccaagucguacucauaaccgcagcaggucuccaagguuaacagccucua
guugauagaauaauguagauaagggaagucggcaaaauagauccguaacu
ucgggauaaggauuggcucuaaggaucgggcacguuuaacgaucaacuua
gaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauu
gugauggucagaaagugauguugacacaaugugauuucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagu
aacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugac
gcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagc
gaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaaga
cccuguugagcuugacucuaguuugacauugugaaaagacauggagggug
uagaauaagugggagcuucggcgccggugaaauaccacuaccucuauagu
uuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucua
gcauuaagcccucugggcgauccggguugaagacauugucagguggggag
uuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaaggg
ggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccc
cuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuauc
gauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuacc
acagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuu
uugauucuucgaugucggcucuuccuaucauaccgaagcagaauucggua
agcguuggauuguucacccacuaauagggaacgugagcuggguuuagacc
gucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauagu
aauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugc
ggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggc
ugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccu
gcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagc
aggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcgg
auagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagau
guacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugc
ugagauuaagcucuuguugucugauuugu
.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<...<<<<
......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.
<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.
>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....
>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<
<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<
<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>
>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<
<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.
<<........>>>>.>>>....>>>>>>>>>...<<.......>>.....
.>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<
<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<..
.....>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<
.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(
((.....<<<<<<.....<<..........<<<.<<<<<<<<<<......
.<<<<<.<<<...<<.........>>...>>>.........<<......>
>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>
.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>
>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>
>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<
<<.....<<<....>>>......{<<<<<<...<<<<.<<<<<<<.<<<<
<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....
>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>
>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>
>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<......
.........>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>
>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<
....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<
.......>>>>>>........<...........<<<<<.......>>>>>
.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>
....>>....<<<<<........>>>>>....<<<<<..<<<.<<.....
.<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<...
..............<......>....................>>.>>.>>
>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>.......
...}...<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>
>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<
<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>
>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))...
...<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>
>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>..
.>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>
...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<
<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<
.<.<<<<<.................>>>>>.><<<<<...<<<<....<<
<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<
<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<
<<.<<<.<.....<<..........<<<<....>>>>......>>.....
..<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..
............>.>>>.>>>>>>..<<<<<<<.............>>..
..<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>
...>>>....>>>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cre Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K6 V7 V9 K13 G18 R19 S22 K26 L29 K33 R38 S45 F49 R50 R60 K61 A62 T63 R64 Y65 N66 K67 P71 F72 H73 F74 R75 K83 A84 R86 G87 M88 P90 H91 K92 T93 A94 R95 R102 F106 G108 V109 P110 P111 Y113 D114 K115 K116 K117 R118 Q123 R129 L130 K131 P132 R134 K135 G147 K149 Y150 L157 E158 K160 R161 K162 S165 Y168 Y169 K172 K173
Binding residue
(residue number reindexed from 1)		K5 V6 V8 K12 G17 R18 S21 K25 L28 K32 R37 S44 F48 R49 R59 K60 A61 T62 R63 Y64 N65 K66 P70 F71 H72 F73 R74 K82 A83 R85 G86 M87 P89 H90 K91 T92 A93 R94 R101 F105 G107 V108 P109 P110 Y112 D113 K114 K115 K116 R117 Q122 R128 L129 K130 P131 R133 K134 G146 K148 Y149 L156 E157 K159 R160 K161 S164 Y167 Y168 K171 K172
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