Structure of PDB 8ove Chain BI Binding Site BS01

Receptor Information
>8ove Chain BI (length=191) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVDLTGVQKKKRVVRHHTYSTNPYIKLLIKLYKFLGKRTNSPFNKLIHKR
LLKSRNNRAPISLSRIAVCMRRRTVWLKKGKKSPIAVIVGDVLDDVRMTR
IPALRICALRFSKSARERITGAGGECLTFDQLAMMAPTGKNTMLLRGRKS
GRESVKHFGAAGVPGSHAKPHVSSRGKERQRSSKRRHAFRH
Ligand information
>8ove Chain BA (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauacaacccuucaugugaguauugagccaaagaaggugucagccc
auuacagccacggagccuacgcgccuccucaagagaguagcacuguuugg
gaaugcagugucaagccggcagguauuugucugccaagguuaaauauaga
guaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagua
cuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugga
aguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuucc
ggggcuaacauccgguggguacugugcggguuucgaggucauggggugcg
ugagugggcggaauaaagggucggugguuguguucuuccuccuucccugu
ccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggaguauugugac
aacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaa
uuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugcc
uguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccgg
ggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucgua
cgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguu
cacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugug
cgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaa
acaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugg
gccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggau
auguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguu
gguggauauccaccggccccgaaaauggaugacgcuuaagccccaugugc
gugauugcccauuauuccuuuggugagggcggcuauaugugagaaagugu
agcccucccgauguagacguggcgugggggugaggacgaagccgauggcg
cgagccucggauggacccgccucuagugcagaucuugguuggcguagcaa
agaucuaacggaauauuuuuaaaugcaacguuggauacuggagcggggaa
ggauuucgugccaacggcacucguacacgaguuguucggucacugagcac
aacguuacaccguuuuguuaggaaagaaaaggggcaacagagaaccuggg
augauauuccaaaaagaauugcauguggg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>.......<<........>>......>>>.<<.......((.....>>))
......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<....
....>>>>>>>......<<<<<........>>>>>..>>>..........
..........................<<....>>................
<<<<....>>>>..................................<<<.
.<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>......
........<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>
>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<........
.>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.
......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<
<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
.<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<
<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>
...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..
<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<
<...<<<(((......<<.<<<<........<...........<<<.<<<
<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>.....
......>>>...>>>>>>><<<<.<<<<<..........>>>>>......
..>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<.
...>>>.>>>.>.....>>>>>>>>..>.....>>>>>>...........
...<<<<<<<..................>>>>>>>...............
.....<<<<<....<<.....>>..>>>>>.....<..........<<.<
<<<<......>>>>.................>.>>..........<<<<.
........>>....>>.>...........
Receptor-Ligand Complex Structure
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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
G2 Q9 K10 K11 K12 R13 R16 H17 H18 Y20 S21 K31 K34 F35 P43 K54 S55 R56 N57 S63 S65 R66 R72 R73 R74 W77 L94 D95 D96 V97 R98 M99 R101 P103 R111 S113 K114 S115 K141 N142 L146 R147 R149 S151 S155 F159 H168 K170 S175 R176 G177 R180 R187 A189
Binding residue
(residue number reindexed from 1)
G1 Q8 K9 K10 K11 R12 R15 H16 H17 Y19 S20 K30 K33 F34 P42 K53 S54 R55 N56 S62 S64 R65 R71 R72 R73 W76 L93 D94 D95 V96 R97 M98 R100 P102 R110 S112 K113 S114 K140 N141 L145 R146 R148 S150 S154 F158 H167 K169 S174 R175 G176 R179 R186 A188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0043232 intracellular non-membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtP50885|RL18_TRYB2 Large ribosomal subunit protein eL18 (Gene Name=RPL18-A)

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