Structure of PDB 6z1p Chain BI Binding Site BS01

Receptor Information
>6z1p Chain BI (length=1413) Species: 312017 (Tetrahymena thermophila SB210) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSNSTVINNFESRSFKNKKNLYNVVAKRSGDVAFSYLNGEYKQNTLDTHM
IKEITRFLESYEIDSSIRAVFLENSKEAGVFSKGTDFKFLMKKIAEKEPH
KAFDYLRELYDFAIFIGKYNKPLLININGLITGSAASIFTRAPFALGSKN
TKWRLNETSLGYIPDAGASYYLSRLNMELGTFLALTGWQIDGYDLSRSGI
AFERMFATHQNIEENWKVAHKKHDQETTSEDLYGLNKFVDLTKQLYYKET
YFSQLNEEVYNRIHKQGEIYYRNENKRLAMAEILYKHQMQDRANLGFKAD
DLFNRSHEILNRLLHYEQCVMFDLGLENIELQTSGTVTSLPLFTIGRCFS
ANSIEEIIERLREEDTHFSRACIKSLESKSPLALKLTLKLLREGINSSWK
ECFEREFRVACRRLLDNEVMRCIQSEIVEEARGFKDWDYKVLSQISKDQV
ESYFRPLVEEKRFEGVSEYQGDLKENCLYPTKDFYRDYPDTVRYYLNQDN
LRDAYQRNSQIYDVEEFLQSHNINSKSPAINIADLREKFYLMEKLNRKKI
EKLNRLSQLSGSEFSIKNFYEVRKAAIDNLFSNKQLVEQKVDEFSAQVFE
DFRNERLQQIKKISQVAAVEKKEDFFMKLRQKIIDERLVESDKLEEITIR
DYPGLQYPLFFPFDNKDNIIETHNPYVKTLFKDVLNQIKVESRGTLVKNY
NFDLKEIESIMEEKEFGKKLIDRLHLQYSDRVNWFNKAREQYEIRYGDYR
GNLVDKWYERLIESGYKVDGIREILQTQTNEQVKQIIQNNVTDNLKDYIY
EFLSDLKVSKSIFEESENTQNQQQLAEEVLKISKEGINQYSNLISLENGQ
KHNIQSNFALKPHEQALELFKKYINHDEELKETLTILLESQQSKSKNSII
EKTRQEMLKLLTQIVQSKLEQIYGKNNYKSCLVTENGEKYYQFDHAFMSR
FDNYITENLEFDIQQYLSTHTLFMFGALGLQRLENLFRRIYNASRKIIQI
LKDYGLEVNSTEELEEFTNYLNNLTSTFASLYVGYKNHLIFSEDKALELQ
NRTKFIKEREQDELSFSNYAIMAYEQKEKFIDQLSALGSQLDEKECEFKV
EFSDQIKSVQRLVEKPLRDGENKEQRIQLIKYQLEKLDDFKLPKKLITGF
VLYAEKLDRLTQTSIHGKAYYVPEKLQIDPEEAQIPEVFEDLDSRMTVQQ
WLDAKLKIFIRKIFNARYQQEKILNHHDLLMLDYEISKFLMPESLKQSMY
EQLDRDMETLRICREYQVSERSKGEAEMQEFLKKKQMEVGKIRNPKAVEK
LNAFRIWREQKYANRDPTAAEFEQIMKIEGELILESTLAPYGQIETDKEI
EKTYLHLLDIQDFSDLDTTRITKEKTLTEEYRLSIDHLKNSIVTKKGDHL
YDDINLFIKQISV
Ligand information
>6z1p Chain Ba (length=196) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaaauaaaaaaaaaauuuauugagugugaucauggcucgggauuaacgcu
aauuagacgccuaacacaugcgaguuuuauaugaguuaaauuaaaauuuu
auuuaaacauauagcgucaaggugaguaauauacaaauauaugccuuuaa
gccuacuuaaauagacgguaacuuuaaaacaguaacaaauguacua
....................<<<<<.........>>>>>...........
.......................<<<..<<<<<..<<<<<<.........
>>>>>>.>>>>>>>>...................................
..<..<<.....>>..>.....<<.........>>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6z1p Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		S27 T28 Y64 K65 Q66 T68 D70 H72 K106 T108 D109 F110 K111 K115 L153 K175 I450
Binding residue
(residue number reindexed from 1)		S4 T5 Y41 K42 Q43 T45 D47 H49 K83 T85 D86 F87 K88 K92 L130 K152 I427
Enzymatic activity
Catalytic site (original residue number in PDB) T108 S157 E180 D188
Catalytic site (residue number reindexed from 1) T85 S134 E157 D165
Enzyme Commision number 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase.
Gene Ontology
Molecular Function
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006574 valine catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6z1p, PDBe:6z1p, PDBj:6z1p
PDBsum6z1p
PubMed32553108
UniProtQ22P47

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