Structure of PDB 4v4w Chain BG Binding Site BS01

Receptor Information
>4v4w Chain BG (length=139) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKG
LPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKIS
RAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVE
Ligand information
>4v4w Chain B0 (length=2740) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguacacgguggaugcccuggcagucaaggcgaugaaggacgugcuaauc
ugcgauaagcgucgguaaggugauaugaaccguuuaaccggcgauuuccg
aauggggaaccccgaucauuauccaaaugaggcgaaccgggggaacugaa
acaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagc
ggcgagcgaacggggagcagcccgagccuaaucaguguguguguugugga
agcgucuggaaaggcgcgcgauacagggugacagccccguacacaaugca
caugcuguagcucgaugaguagggcgggccgugguaccugucugaauaug
gggggaccauccuccaaggcuaaauacucugacugaccgauagugaacca
guaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaaga
accugaaaccguguacguacaagcagugggaggcaccuuaugcguguuau
ggcgugccuuuuguauaaugggucagcgacuuauauucuguagcaagguu
aaccggggagccgaagggaaaccgagucuuaacgggcguuaaguugcagg
guauagacccgaaacccggugaucuagccaugggcagguugaagguuggg
uaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaug
acuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucu
ccccgaaagcuauuuagguagcgccucgugaaucaucuccggggguagag
cacuguuucggcaagggggucgacuuccaacccgaugcaaacugcgaaua
ccggagauguuaucacgggagacacacggcggguguaacguccgucguga
agagggaaacaacccagaccgcagcuaaggucccaaagucaugguuaagu
gggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagca
gccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgc
ggaagauguacggggcuaaaccaugcaccgaagcugcggcagcgacguua
ugcguuguuggguaggggagcguucuguagccugcgaaggugugcuguga
ggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaa
gcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguu
aaucggggcagggugagucgacccuaaggcgaggccgaaaggcguagucg
augggaaacagguuaauauuccuguacuuggugugugggugauggaggga
cggagaaggcuauguuaugccaagcuauggcugcugguugguacgcucaa
gggcgaucgggucagaaaaucuaccggucacaugccucagacguaucggg
agcuuccucggaagcgaaguaacaaagcccucuuccaggaaaagcuucua
aacguugaaacaugucaaaucguaccccaaaccgacacagguggucaggu
agagaauaccaggcgcuugagagaacucgggugaaggaacuaggcaaaau
ggugccguaacuucgggagaaggcacgcugauuagcucgccugaucaguc
gaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaa
acacgaaaguggacguauacggugugacgccugcccggugccggaagguu
aaugggguugcaaagcucucgaagccccgguaaacggcggccguaacuau
aacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcac
gaauggcguaaugauggccaggcugucuccacccgagacucagugaaauu
gaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccg
ugaaccuuuacuauagcuugacacugaacauugagccuugauguguagga
uaggugggaggcuuugaaguguggacgccagucugcauggagccggccuu
gaaauaccacccuuuaauguuugauguucuaacccgaauccggggacagu
gucugguggguaguuugacuggggcggucuccuccuaaagaguaacggag
gagcacgaagguuggcuaauccuggcaucaggagguuagugcaauggcau
aagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggu
cauagugauccgguggucugaauggaagggccaucgucaacggaaaaggu
acuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgg
uguuuggcaccucgaugucggcucaucacauccuggggcugaaguagguc
ccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuag
aacgucgugagacaguucggucccuaucugccgugggcggagaacugagg
ggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguuc
ggguugucagccauggcacugcccgguagcuaaaugcggagagauaagug
cugaaagcaucuaagcacgaaacuugccccgagaugaguucucccgaagg
aacguugaagacgacgacguugauaggccggguguguaagcgcagcaaug
cguugagcuaaccgguacuaaugaaccgaggucuugacca
<<<<<<<<<<.....<<..<<<<<<<<<<<<.........<<<.[...((
.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>.......
....<<...>>....<<<<<.....>>>>>.>>...<<<<<<.....<..
....>......>>>>>.>.........<<....>>..<<<<<<.....<<
.....>>....>>>>>>..<<<.<<<<.....<<<<<<...<.<..<...
..<<<<......>>>>.(.......<<<......)>>>....>.>..>..
.>>>>>>..>>>>........<<<<<<<........>>>>>>>......<
<<<<..[[..>>>>>..>>>......>>.>>>>>>.>>............
...<<....>>....>>.........<<<<.....>>>>...........
.......>>>>>>>>>>.........<....<<<<<.......>>>>>..
.>....<.<........>.>.<<<<<<......<<<<<<<<.<<..<<<.
.........>>>...<<....>>..<<<<....>>>>.....>>.>>>>>
>>>....<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<.
.....>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>...
.>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<
<<<<....<<<<<....>>>>>..<<...<<..<<...<<<<.<....<<
...<...<<<<...<<<<<<..>>>>>>...>>>>...>..>>.....>.
>>>>...>>...>>...>>......<<<<<<<<.......>>>>>>>>..
...<<<......>>>...<<<<<<<...<<<((......<<<<<.<....
.......<..<<<<<..<<........<<<<<.<<...<<<<.......>
>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>
............)).....>>>>>>.>>>...>>>>>>>..<<<<<<<..
.>>>>>>>......>>>>>>...<<<<..<<<<.....<<<<<<<<....
>>>>>>>>..>>>>..>>>>.........>>>>>><.............<
<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<..
...>>.>>>>>>....((<<<<<....<<<.<.<<<....>>>.>.>>>.
...>>...<<<<........>>>>.))<<<<..<<<........<<<...
.<<<<<.<<<..<<<<..<<<<.<<...(((.>>>>>>..<<<<<.<<.<
<<..<<<<<.<............>>>>>>.....>>>..>>>>>>>....
.<<<........>>>.....>>>>..>>>.>>>>>.........>>>...
.........>>>..>>>>.>>>..>>.....<<......>>>>>>>..<<
<.....>>>..>>>>..<<<.........<<...<<..............
.<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
.<<<....>>>.......>>>>>>>..<<<<..<<....<..<<..<<<.
...<<<<<......>>>>>....>>>>>..>....>>.<<<<<<......
.>>>>>>....................<<<<<<.....>>>>>>......
....>>>>...>>.>>>>>>>.....>>....>>.....>>>.......>
.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.......<<<
...<<.<...<..............<<<<<<<<<<<.<<.<.........
..................................................
..............>>>.>>>>>>>>>>>...<<<<....>>>>......
............>...<<<<.....>>>><<<<<<...........>>>>
>>..<<...<<<<<<<...<<<<<....>>>>>.....<<...(((>>..
..>>>>>>>...<<<<..<<........>>..>>>>.<<<....>>>.>>
))).........<<<<<<<....]]..>>>>>>>.............>>>
....>.>>.........<<.<.<<<<<<...<<.......>>...>>>>>
>...>>>..........<.........<<....<<<<<<<......>>>>
>>>.......<<.......>>.......>>..............>....<
<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>...<<<<....<<
<<..<<<<<<.................>>>>>>.<<<<<...<<<<..<<
<<<<.<<<<))).>>>>...>>>>>>..>>>>.>>>>>..<<<.<..<<<
<<...........>>>>>...>>>>.>>>>........>>>>......<<
..<<<<.........>>>>....<<<<<<<<..<<....<<<........
>>>...>>...>>>>>.>>>.....>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v4w Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements
Resolution15.0 Å
Binding residue
(original residue number in PDB)		Q11 G90 K91 N93 T117 G118 R126 S127 G130 T131 S134 M135
Binding residue
(residue number reindexed from 1)		Q10 G89 K90 N92 T116 G117 R125 S126 G129 T130 S133 M134
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006415 translational termination
GO:0015968 stringent response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v4w, PDBe:4v4w, PDBj:4v4w
PDBsum4v4w
PubMed16713583
UniProtP0A7J7|RL11_ECOLI Large ribosomal subunit protein uL11 (Gene Name=rplK)

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