Structure of PDB 5aj0 Chain BF Binding Site BS01

Receptor Information
>5aj0 Chain BF (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKA
QCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVN
AIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFR
NIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
Ligand information
>5aj0 Chain B1 (length=1708) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucua
gagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgu
gcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccu
cgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucug
cccuaucaacuuucgaugguagucgccgugccuaccauggugaccacggg
ugacggggaaucaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgg
ggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaa
uuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaa
gucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaa
guugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugc
cucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
ccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguu
cuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgg
gggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaaga
cggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacg
aaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaa
acgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucu
uagagggacaaguggcguucagccacccgagauugagcaauaacaggucu
gugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcuc
agcgugugccuacccuacgccggcaggcgcggguaacccguugaacccca
uucgugauggggaucggggauugcaauuauuccccaugaacgaggaauuc
ccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuugu
acacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucgg
aucggccccgccguggcggagcgcugagaagacggucgaacuugacuauc
uagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaag
gaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[[[....<<.....<<.<<<.....>>>
.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>
[[..(((((.....<<<<<<<<.<<.>>....<......>..)))))...
...]]...<<<<..<<<......>>>.>>>>.]].]]]...}}....]]]
.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.
>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>
>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>
>>>......<<..<...........>..>>.........<<<<<((....
..<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]..
..........{{.......{{...[[[.......<<<.....>>>....<
.<..<....>>.>....<<<<<.<.......<<...<.......>.<<<<
.......>>>>...>>......>.>>>..>>...........[...((((
((......>>>>>>>>.))))))...]............<<<<<<..<..
.<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..
>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}...
...<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.....
.....<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..
>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>
>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<..
......<<.<<<........>>>.>>......>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>
>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>..
...>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<...
.....<.......<<<.<<<<....>>>>.>>>....>.........>>>
.>>......<.....<<<<<..........>>>>>.....>.....>>>>
>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<..
.<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>
>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5aj0 Structural Snapshots of Actively Translating Human Ribosomes
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H51 A57 A58 K59 R60 N74 M76 M77 M78 H79 G80 R81 N82 N83 K85 K86 L87 M88 R91 N148 R159 F163 R164 N165 I166 T168 I169
Binding residue
(residue number reindexed from 1)		H37 A43 A44 K45 R46 N60 M62 M63 M64 H65 G66 R67 N68 N69 K71 K72 L73 M74 R77 N134 R145 F149 R150 N151 I152 T154 I155
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006450 regulation of translational fidelity
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum5aj0
PubMed25957688
UniProtP46782|RS5_HUMAN Small ribosomal subunit protein uS7 (Gene Name=RPS5)

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