Structure of PDB 9f1d Chain BE Binding Site BS01

Receptor Information

>9f1d Chain BE (length=243) Species: 9986 (Oryctolagus cuniculus)

PKKGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYAAPKSRIERKKKR
EKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQ
HVRKLRASITPGTILIILTGRHRGKRVVFLKQLSSGLLLVTGPLSLNRVP
LRRTHQKFVIATSTKIDISGVKIPKHLTDAYFKKKKLRKPEKEKYEITEQ
RKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVF

Ligand information

>9f1d Chain B5 (length=3706)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaau
guggcguacggaagacccacuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcgugguccggccgugccggcg
gucucggcggaucuuucccgcuccccguuccuggggguggggucggcggg
ggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgc
ggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcgggg
aagguggcccggggggacgccucgccgccgucguccgcggcggcggcggg
cgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgc
cgaaucccggggccgagggagcgagaccugugucgccgcgcucucccccc
ucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacu
guccccagugcgccccgggcgugucacgccgucgggcucgggggaggcca
cggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggc
ggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagu
cuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaau
gaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccga
ggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgc
gccggggagguggagcacgagcgcacguguuaggacccgaaagaugguga
acuaugccugggcagggcgaagccagaggaaacucugguggagguccgua
gcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaag
acuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggau
agcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauua
gaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggg
uaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccu
agugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacg
ccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaaggugu
ugguugauauagacagcaggacgguggccauggaagucggaauccgcuaa
ggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaug
gcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagc
gagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggcc
gcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgc
aggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaag
gccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagu
cgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccu
ccguugcccucagccgaucgaaagggagucggguucagauccccgaaucc
ggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccg
aucccggagaagccggcgggagccccggggagaguucucuuuucuuugug
aagggcagggcgcccuggaauggguucgccccgagagaggggcccgugcc
uuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccu
ugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauau
ccgcagcaggucuccaaggugaacagccucuggcauguuggaacaaugua
gguaagggaagucggcaagccggauccguaacuucgggauaaggauuggc
ucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauc
cgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguuga
cgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauuca
augaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauu
cccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggc
uuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucu
ggcacggugaagagacacguuuuuucacugacccggugaggcgggggggc
gagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucggu
ccgggccggcggcggccgggcgcgacccgcuccggggacagugccaggug
gggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccu
aaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaa
gcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggc
cucacgauccuucugagcuuuuggguuuuaagcaggaggugucagaaaag
uuaccacagggauaacuggcuuguggcggccaagcguucauagcgacguc
gcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauu
caccaagcguuggauuguucacccacuaauagggaacgugagcuggguuu
agaccgucgugagacagguuaguuuuacccuacugaugauguguuguugc
caugguaauccugcucaguacgagaggaaccgcagguucagacauuuggu
guaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggau
uaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacgg
cagcgccgaaggagccucgguuggccucggauagccggucccccgcgggg
uccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagg
gggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcg
cuaaaccauucguagacgaccugcuucugggucgggguuucguacguagc
agagcagcucccucgcugcgaucuauugaaagucagcccucgacacaagg
guuugu

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>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<......>>
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>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.
>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<
......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>
........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>
>>...>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<
<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<
<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.
>><<<<<.<<<<<<<..>>>>>>>>>>>>.....>>>>>......>>.>>
>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....
<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<
....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..
<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<....
..>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<..
...<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...
<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<......
.>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.
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.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<
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.....<<......>>...>>>>>...>>>>>>>>>>>>>..........)
)).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...
........}}.))))..............>>>>>>>>>....>>>>>>.<
.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>
>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.
<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((
<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...
>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<
<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<.
.<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>...
.<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>
>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>...
......>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....
<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<
<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.
<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<
<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>
.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.
<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<
<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>.
.>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<.
..<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....
>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)
))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>
>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>
>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>
>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<
..<<<..<.<<<<<.................>>>>>.><<<<....<<<<
....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<.
..<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>....
.<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>
.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<.......
.>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>
>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.
<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>
>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9f1d NAC guides a ribosomal multienzyme complex for nascent protein processing.
• Resolution: 3.26 Å
• Binding residue (original residue number in PDB): G42 H45 C46 S47 R48 R54 S60 R61 S62 M64 Y65 S66 R67 K68 Y71 K72 R73 Y75 A77 K79 R84 K85 K86 R88 V91 A93 T94 P98 V99 G100 G101 K103 N104 R108 V110 K111 K114 P116 R117 Y118 R126 K127 L128 L129 H131 K133 K134 P135 F136 S137 H139 K142 T157 G158 R159 H160 R161 L175 L182 L184 R186 P188 R190 R191 H193 K195 F196 F220 K222 R226 K242 Y243 I245 R249 K250 K265 Q269 Q271 R275 V277 N282
• Binding residue (residue number reindexed from 1): G4 H7 C8 S9 R10 R16 S22 R23 S24 M26 Y27 S28 R29 K30 Y33 K34 R35 Y37 A39 K41 R46 K47 K48 R50 V53 A55 T56 P60 V61 G62 G63 K65 N66 R70 V72 K73 K76 P78 R79 Y80 R88 K89 L90 L91 H93 K95 K96 P97 F98 S99 H101 K104 T119 G120 R121 H122 R123 L137 L144 L146 R148 P150 R152 R153 H155 K157 F158 F182 K184 R188 K194 Y195 I197 R201 K202 K217 Q221 Q223 R227 V229 N234

External links

• PDB: RCSB:9f1d, PDBe:9f1d, PDBj:9f1d
• PDBsum: 9f1d
• PubMed: 39169182
• UniProt: G1SKF7|RL6_RABIT Large ribosomal subunit protein eL6 (Gene Name=RPL6)