Structure of PDB 6ydw Chain BC Binding Site BS01

Receptor Information

>6ydw Chain BC (length=694) Species: 9606 (Homo sapiens)

VIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVM
DSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLD
GAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQ
MRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIP
AELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLK
RSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKKTKILMNS
SRDNSHPFVGLAFKLEVGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQRL
ARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPD
PVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGE
LHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKKQSGGAGQ
YGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKGFLDACEKGP
LSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEP
IMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADVPLNDMFG
YSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLEATGQL

Ligand information

>6ydw Chain AA (length=960)

acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugc
aaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaag
gagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaa
ccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaa
guuugacuaaguuauauuaauuagaguugguaaaucucgugccagccacc
gcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguu
uaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagc
ccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacac
acgauagcuaggacccaaacugggauuagauaccccacuaugccuagccc
uaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgca
acugccuaaaacucaaaggacuuggcggugcuucacauccaccuagagga
gccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaa
uucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauagu
aagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggg
uuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaa
aguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaa
uagagugcuugauugaauaaggccaugaagcacgcacacaccgcccguca
cccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaac
caugcaagaagagacaagucguaacaagguaagcauacuggaaagugugc
uuggauuacc

..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<
..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>
>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....
>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....
>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>
)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<.
..<<..............<<<<<<.....<.<<<<<<.<<<......>>>
..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>
>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..
........<<<<<<......))...>>>>>>.>>>.<<<........<<.
...>>......>>>..>>>>>><<<<<.<<<<<<.....<..<<<<<..<
<<<<<<<<<.....<<........>>..........<<<<<<<.......
...<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>
..>>......<<.....>>..........>>>...>>>>>>>>>...>>>
>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<...
.<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<..
.......>>>>>>>......>.....>>>>>>>>>.>>....<..<<.<.
..<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....
>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>
>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ydw Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1.
• Resolution: 4.2 Å
• Binding residue (original residue number in PDB): Q396 S543 Q548 K580 I624
• Binding residue (residue number reindexed from 1): Q348 S495 Q500 K532 I576

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0070125 mitochondrial translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:6ydw, PDBe:6ydw, PDBj:6ydw
• PDBsum: 6ydw
• PubMed: 32602580
• UniProt: Q96RP9|EFGM_HUMAN Elongation factor G, mitochondrial (Gene Name=GFM1)