Structure of PDB 4v6u Chain BC Binding Site BS01

Receptor Information
>4v6u Chain BC (length=365) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGKVHRPRRGSLGFSPRKRAKSIVPRIRSWPKETEVRMLGFAGYKAGMTH
ILMIDDEPGLTNGKEIFMPVTIIETPPLRVFGIRAYRMGYLGLETATEVI
VPDFPLDNYPAKERKGKPKPKMTFYKLLERRIATLPKNYTQEMFEQKLGQ
LEDMIKEGEIVDVRAIVATQPWVIKLKKKPEVMEYAIGGTSVEEKFNYIK
EKLGKELRVGEVLKEGELLDVIAVTKGKGTQGPVKRWGIKLRAHKDSKGR
RKVGSIGPWHPARVMWTVPMAGQMGFHHRTELNKRLIAIGENGKLKLDEN
TEIEITPKGGFPHYGIVRSDFMMIAGSVPGAIKRIIRVRPAIRPPKKKPP
VQRPQITYVSVESKQ
Ligand information
>4v6u Chain B1 (length=3049) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcuaggacgcuaagccgcccgguggauggcucggcucggggcgccgac
gaagggcguggcaagcugcgauaagccccggcgaggcgcaggcagccguc
gaaccggggauucccgaaugggaccucccgcggcuuaugccgcacuccgg
gguuuauccccggagggggaacgcggggaauugaaacaucuuaguacccg
caggaaaagaaagcaaaagcgaugccgugaguaggggcgaccgaaaacgg
cagagggcaaacugaaccccgggccgacgagguucgggggaugugggguu
guagggcccccguaugagacccucgcgggugaagccgaaguccgcuggaa
cgcggcgccggagagggugauagccccguaggcguaagcccgcagggucu
cgggggacccugaguaccgucgguuggauauccggcgggaagcugggagg
caucggcucccaacccuaaauacgucccgagaccgauagcgaacuaguac
cgugagggaaagcugaaaagcaccccgggaggggggugaaaagagccuga
aaccgggcggcgauaggagggugcggcccgaaaggaaugagccuccccga
aggaaaccgcggcgacgcgggaguacgaggggaggggaccgggguugcac
cguccgucuugaaacacggggcagggaguucgcggccguggcgagguuaa
ggggguuaagccccguagccgcagggaaaccgacaugcccgcagccgggc
uuaugcccggugaggggcggggugcgaaagcgcccggagucacggccgcg
agacccgaaaccggucgaucuagcccggggcagggugaagucccucaacc
gagggauggaggcccgcuaggggugcugaugugcaguucgcucccgugac
cccgggcuaggggugaaaggccaaucgaggccggagauagcugguucccg
ccgaaucaucccgcaggauggccuccccggagguaggcggugggguagag
cacugauuggaggugcagggggcgaaagcccccggccuccugucaaacuc
cgaacccaccgccgccguagauggggggaguaggguggcgguguaagccg
uccaccgagaggggaacaacccagaccgggguuaaggccccaaagugccg
gcuaaguguuacuccaaagggugucccgggccuuagacagcggggaggua
ggcuuagaagcagccauccuuuaaagagugcguaacagcucacccgucga
gguccggggccccgaaaauggacggggcucaagccggccgccgagacccc
ggcgcacggaccgauugguccgugaucggguaggcgggcgugccgguggc
guagaagccgggccguaagguccgguggagccgccgguaucgcggauccu
gccgggaguagcagcguagucgggugagaaucccgaccgccggaggggcc
aggguuccacggcaauggucgucagccguggguuagucgguccuaacccc
gcccguaacucggcgcgggggaaagggaaacggguuuauauucccguacc
gcggggguaggugcggcaacgcaagcccggagggugacgccucgggguag
gcggaccggccgaugaggccggcuaagcguauaagcccggggagugccgu
aauggcgagaaccgggugaaagcgcgaauggcccccccguuagggggguu
ccgccgaucccuggggcccgugaaaagcccuccgggaauuccgauccccc
gcgaccguaccgagaaccgacacaggugccccugggugagaagccuaagg
cgugucgggggaaacccggccgagggaacucggcaaacuggccccguaac
uucgggagaaggggugccugcgggugcguaacccgcaggucgcagugacu
aggggggcccgacuguuuaauaaaaacacaggucccagcuagcccgaaag
gguuuguacuggggccgacgccugcccagugccgguaugugaagcccggg
uacaaccgggugaagcaccgguaaacggcggggguaacuauaacccucuu
aagguagcgaaauuccuugucgguuaaaugccgaccugcaugaauggcgu
aacgagguccccgcuguccccggccggggcccggcgaaaccucugccugg
cgcgcaugccagggacccccggugggaagcgaagaccccauggagcuuua
cugcagccugccguugccacacggcggggggugcgcagcguaggcgggag
gcgucgaagcccggccuccgggucggguggagccguccaugagacaccgc
ccacuccccgcuguguggcuaacccccgaaaggggggacagcgguaggug
ggcaguuuggcuggggcggcacgccuccgaaaagguaucggaggcgcccu
aaggucggcucaggcgggucaggaauccgccguagagugcaagggcaaaa
gccggccugacuggacccguaacagaggcggguccagccccgaaagggug
gccuagcgaaccccugugccuccccggugggggccagggaugacagaaaa
gcuacccuggggauaacagagucgucucgggcgagagcccauaucgaccc
cgaggcuugcuaccucgcugucggcucuucccauccuggcccugcagcag
gggccaaggguggggguguucacccauuaaaggggaacgugagcuggguu
uagaccgucgugagacaggucggaugcuaucuaccggggguguuggccgc
cugaggggaaggugccccuaguacgagaggaacagggugccgcggccucu
ggucuaccgguuguccucccgggcaucgccgggcagcuacgccgcagccg
auaaggccugaaagcaucuaaggccgaagcggcccccgaaaauaggcggc
cguucccuggcgcuugggccugggcgaccggcccauugccagggacgagg
gcucggguagaagacccgguugauagggcggggauguaagcgggaagggu
caaccgacccgcuuaguccgccgccccuaaucgcccgagguccugcccc
<<<.<<<<.......<<<<<<<<<<.....((..((<<<<<<<<.<<...
...<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>...
...>>>>>>...>>>....<<<...>>>.<<<<<....>>>>>..<<<<<
<<.....>>>>>>>..>>...<<<<<<.....<......>......>>>>
>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>
>>..<<<....<<...<<<<<<<<<.....>>>>>>>>>.....>>....
......<<<.<....<.<<<<<<.<<<<<<...<<<.....<<<<.....
.>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>.
>>>>>...........<<<<<<<........>>>>>>>......<<<<<.
<<<<<<>>>>>..>>>.......>>>>>>>>.))...............<
<....>>....)).........<<<<.....>>>>...............
.>>>>>>>>>>........<<<<<<<<<<....<<......<<<<<<<..
......<<<<<....>>>>>........>>>>>>>...>>.>>>>>>>>>
>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...
.<<<<.....>>>>...>>>...<<....>>....<<<<<...<<<<<<<
....>>>>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>
>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....
>>>>>>>.....>>>....<<<<.<<.<<........>>>>>>>>....>
>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<
<<....<<<<<....>>>>><<<<<<<<<..<<<.<<<<<<<<<...<<<
...........<..<<..<<<<.......>>>>.>>.>.........>>.
>...>>>>>>>>>>>>.....>>>>>>>.>>.<<..<<<<<<....>>>>
>>..>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<
<<.....<<.........<<<.<<<<<<<<<<.......<<<<..<<...
<<<<.......>>>>...>>.........<<......>>....>>>>...
>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>
>><<<<<<<<<<....>>>>>>>>..>>....>>>>>><.<<<<<<<<<<
......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>
>>><<.....<<......<<<<<<.......>>>>>><<<<....<<<<.
.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<
<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>))<
<<<<<<<.....<<<....>>>......<<<<<<<...<<<<<<<<<...
<..<.<<<<<<.....>>>>>><...<<<<....<<<<<<.....<<<<.
..>>>>.....>>>>>>....>>>>....><.<<<<<......>>>>>.>
.>..>...>>>>>>>>>.........>>>>>>>............>>>>>
>>>>>>>..>>.....<<......>>.>>>>..<<<<.....>>>>..>>
>>...<<<<.....<<<<<<<<.<<...............<<<<<.....
..........>>>>><<<<<<<<<<.....>>>>>>>>>>..........
..<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>
>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<<<<<.
.....>>>>>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>..
......<...........<<<<<<.....>>>>>>.....>....>>>>>
..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>....>>....<<<<<
........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<
<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<
<<......<<<<<<<<....>>>>>>>>...>>>............>>>>
>.>>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>>>>>.
.>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<.
..<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....
>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>
>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>
>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>
>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>
>>>>>>..>>..<<<.......>>>......>>>>>..>...>>>.>>..
..<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<
<<..<<<<..<<<<<<<.................>>>>>>><<<<<...<
<<<...<<<<<<<<<<....>>>>>..>>>>>...>>>>.>>>>>.<<<<
.<..<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>
>..<<<.<<<<<..<<<<<<.<<....>>>>>>>>.>>>>>>>>....<<
<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<..
...>>..>>>>>...>>>>.>>>>>.>>>...>>>>.....>>>>.>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v6u Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution.
Resolution6.6 Å
Binding residue
(original residue number in PDB)
M1 G2 K3 V4 H5 R6 R8 R9 G10 S11 L12 G13 F14 S15 P16 R17 K18 R19 K21 R26 I27 R28 S29 K45 M48 T49 G59 L60 P69 R84 L93 E94 T95 A96 E98 E113 R130 I132 T134 P136 K137 E142 R164 K175 L176 K178 K179 M183 E184 T225 K226 G227 G229 T230 Q231 G232 V234 K235 R236 I239 K240 L241 R242 A243 H244 K245 S247 R251 K252 V253 G254 S255 I256 G257 P258 W259 H260 P261 A262 R263 V264 M265 T267 M270 A271 G272 Q273 F276 H278 R279 T280 E281 L282 N283 K284 K308 G309 F311 H313 Y314 G315 S327 V328 P329 G330 K333 R334 R343 K347 K348 K364 Q365
Binding residue
(residue number reindexed from 1)
M1 G2 K3 V4 H5 R6 R8 R9 G10 S11 L12 G13 F14 S15 P16 R17 K18 R19 K21 R26 I27 R28 S29 K45 M48 T49 G59 L60 P69 R84 L93 E94 T95 A96 E98 E113 R130 I132 T134 P136 K137 E142 R164 K175 L176 K178 K179 M183 E184 T225 K226 G227 G229 T230 Q231 G232 V234 K235 R236 I239 K240 L241 R242 A243 H244 K245 S247 R251 K252 V253 G254 S255 I256 G257 P258 W259 H260 P261 A262 R263 V264 M265 T267 M270 A271 G272 Q273 F276 H278 R279 T280 E281 L282 N283 K284 K308 G309 F311 H313 Y314 G315 S327 V328 P329 G330 K333 R334 R343 K347 K348 K364 Q365
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4v6u, PDBe:4v6u, PDBj:4v6u
PDBsum4v6u
PubMed23222135
UniProtQ8TZZ8|RL3_PYRFU Large ribosomal subunit protein uL3 (Gene Name=rpl3)

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