Structure of PDB 8oh8 Chain BBB Binding Site BS01

Receptor Information
>8oh8 Chain BBB (length=303) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMSQVTIKDIEVLNCEYGKNTIKFLRLHREGKKHFVKEVEVCTHLRLT
SAHEYLDGNNSFVIPTDTIKNIVLVLAKKNGISSIEQFAIDICKHFMTTF
CQVAYVKTYIQEVPWQRQYQNGVPHIHSFILVPDGIRFCEAEQCRNGPLV
VCAGIKDLKLMKTTQSGFEGFYRNEHTTLPERNDRILCGEFFCKWSYGEC
RDFDFDCIWSKVRECILEAFSGPPDCGEYSPSYQRTVNCIQMCVLSRVPQ
VQVIEVILNNNFYNVVDMKALGCTNDKEVLVPVETPYGSCACTLGRKKYL
EAQ
Ligand information
Ligand IDAZA
InChIInChI=1S/C4H3N5O2/c10-3-1-2(8-9-7-1)5-4(11)6-3/h(H3,5,6,7,8,9,10,11)
InChIKeyKVGVQTOQSNJTJI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC(=O)c2nn[nH]c2N1
OpenEye OEToolkits 1.5.0c12c([nH]nn1)NC(=O)NC2=O
ACDLabs 10.04O=C2Nc1nnnc1C(=O)N2
FormulaC4 H3 N5 O2
Name8-AZAXANTHINE
ChEMBLCHEMBL219341
DrugBankDB01875
ZINCZINC000018123155
PDB chain8oh8 Chain AAA Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8oh8 Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		Y16 P62 T63
Binding residue
(residue number reindexed from 1)		Y19 P65 T66
Annotation score2
Enzymatic activity
Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oh8, PDBe:8oh8, PDBj:8oh8
PDBsum8oh8
PubMed37695804
UniProtA0A8V0ZED1

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