Structure of PDB 7zx1 Chain BBB Binding Site BS01

Receptor Information
>7zx1 Chain BBB (length=629) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIIRDDGFPIKGCDDT
LVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKESDKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMETSSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQ
KENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIET
QAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHPLPGL
ILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTE
PNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELRILAH
LSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIY
GMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQ
TILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQ
LETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNE
MESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
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PDB7zx1 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.829 Å
Binding residue
(original residue number in PDB)		A2238 N2248 Y2391 M2393 G2394 S2397 R2448 Y2459 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		A342 N352 Y450 M452 G453 S456 R507 Y518 H522 R525 N529 Q533
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx1, PDBe:7zx1, PDBj:7zx1
PDBsum7zx1
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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