Structure of PDB 7zx0 Chain BBB Binding Site BS01

Receptor Information
>7zx0 Chain BBB (length=629) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIIRDDGFPIKGCDDT
LVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKESDKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMETSSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQ
KENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIET
QAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHPLPGL
ILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTE
PNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELRILAH
LSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIY
GMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQ
TILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQ
LETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNE
MESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
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PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		T2128 A2238 T2243 N2248 G2388 Y2391 M2393 R2448 Y2459 R2460 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		T263 A342 T347 N352 G447 Y450 M452 R507 Y518 R519 H522 R525 N529 Q533
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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