Structure of PDB 7zus Chain BBB Binding Site BS01

Receptor Information
>7zus Chain BBB (length=639) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIIRDDGFPIKGCDDT
LVVGLAVCWGGRDAYYFSLQKEQPSLDPSLTLKDRMWYLQSCLRKESDKE
CSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIV
TSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQ
LNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAK
LDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKAL
HPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATG
RITFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLE
LRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQI
CYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCK
RDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIAT
VNIQKQLETFHSTFKSHGHREGMLQCPIRGGFFILQLHDELLYEVAEEDV
VQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zus Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		A2238 T2243 T2245 N2248 Q2384 G2388 Y2391 M2393 G2394 S2397 R2448 Y2459 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		A348 T353 T355 N358 Q449 G453 Y456 M458 G459 S462 R513 Y524 H528 R531 N535 Q539
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zus, PDBe:7zus, PDBj:7zus
PDBsum7zus
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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