Structure of PDB 7z43 Chain BBB Binding Site BS01

Receptor Information
>7z43 Chain BBB (length=750) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGF
LIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIR
GFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGIS
MTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIA
RLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEE
GTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALF
VNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDG
FVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQL
FIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYN
LRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPAHG
PVKKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACF
NSASYRKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z43 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution3.123 Å
Binding residue
(original residue number in PDB)		R126 Q127 M227 K229 D230 I241 T243 R249 M410 M412 N414 N670 R671 S672 N675
Binding residue
(residue number reindexed from 1)		R127 Q128 M228 K230 D231 I242 T244 R250 M411 M413 N415 N671 R672 S673 N676
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z43, PDBe:7z43, PDBj:7z43
PDBsum7z43
PubMed35605026
UniProtQ5V8Y6

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