Structure of PDB 7q5t Chain BBB Binding Site BS01

Receptor Information
>7q5t Chain BBB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAH
GRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF
NRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKL
IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCL
LHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTV
PCQKIGT
Ligand information
>7q5t Chain KKK (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GVYTGLSTRNQETYETLKH
Receptor-Ligand Complex Structure
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PDB7q5t The tandem SH2 domains of SYK
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R22 R42 H63 Y64 T65 G79 G98 R175 R195 R197 H215 Y216 R217 E230 G231 K232 K247 D249 G250
Binding residue
(residue number reindexed from 1)		R15 R35 H56 Y57 T58 G72 G91 R168 R188 R190 H208 Y209 R210 E223 G224 K225 K240 D242 G243
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5t, PDBe:7q5t, PDBj:7q5t
PDBsum7q5t
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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