Structure of PDB 7plr Chain BBB Binding Site BS01

Receptor Information
>7plr Chain BBB (length=184) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMDYQEYQQFLARINTARDACVAKDIDVDLLMARHDYFGRELCKSLNIEY
RNDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSN
ESSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELY
PTIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7plr Chain BBB Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7plr Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir
Resolution2.64 Å
Binding residue
(original residue number in PDB)		H34 D79 D92 Y93
Binding residue
(residue number reindexed from 1)		H35 D80 D93 Y94
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
External links
PDB RCSB:7plr, PDBe:7plr, PDBj:7plr
PDBsum7plr
PubMed38656310
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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