Structure of PDB 7nt0 Chain BBB Binding Site BS01

Receptor Information
>7nt0 Chain BBB (length=170) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QANLGRLLSRSDWGARLPKSVEHFQGPAPYVIIHHSYMPAVCYSTPDCMK
SMRDMQDFHQLERGWNDIGFSFGIGGDGMIYTGRGFNVIGAHAPKYNDKS
VGIVLIGDWRTELPPKQMLDAAKNLIAFGVFKGYIDPAYKLLGHRQVRDT
ECPGGRLFAEISSWPHFTHI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7nt0 Chain BBB Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7nt0 PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H42 H152 C160
Binding residue
(residue number reindexed from 1)		H34 H144 C152
Annotation score4
Enzymatic activity
Enzyme Commision number 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016787 hydrolase activity
GO:0042834 peptidoglycan binding
GO:0046872 metal ion binding
Biological Process
GO:0002814 negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0009253 peptidoglycan catabolic process
GO:0045087 innate immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0061060 negative regulation of peptidoglycan recognition protein signaling pathway
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nt0, PDBe:7nt0, PDBj:7nt0
PDBsum7nt0
PubMed34066955
UniProtQ8INK6|PGPLB_DROME Peptidoglycan-recognition protein LB (Gene Name=PGRP-LB)

[Back to BioLiP]