Structure of PDB 6yvr Chain BBB Binding Site BS01

Receptor Information
>6yvr Chain BBB (length=470) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARKKSLQSLQ
SRVDYYLGSLALSDLLILLFALPVDLYNFIWVHHPWAFGDAGCKGYYFLR
EACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASAL
LAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLRVVIQLNTFMSFLFP
MLVASILNTVAARRLTVMVHQIEPGRVQALRRGVLVLRAVVIAFVVCWLP
YHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLAE
DLVEDWEKARKLLEAARKGQDDEVRILLANGADVNTADETGFTPLHLAAW
EGHLGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGV
NATDVIGTAPLHLAAMWGHLEIVEVLLKNGADVNAQDKFGKTPFDLAIDN
GNEDIAEVLQKAATRELEVL
Ligand information
Receptor-Ligand Complex Structure
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PDB6yvr Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Resolution2.458 Å
Binding residue
(original residue number in PDB)		D54 L55 F128 H132 Y146 V224 T226 R327 F331 I334 D336 W339 F344 Y347
Binding residue
(residue number reindexed from 1)		D5 L6 F79 H83 Y97 V175 T177 R254 F258 I261 D263 W266 F271 Y274
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016492 G protein-coupled neurotensin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yvr, PDBe:6yvr, PDBj:6yvr
PDBsum6yvr
PubMed33571132
UniProtP20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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