Structure of PDB 8fkr Chain BA Binding Site BS01

Receptor Information
>8fkr Chain BA (length=156) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRIT
VKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEI
VNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGA
VECPAS
Ligand information
>8fkr Chain L3 (length=1767) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaccucagaucagacguggcgacccgcugagcauauuagucagcggag
gagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaag
agcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgg
aagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucg
aggcccagcccguggacggugugaggccgguagcggcccccggcgcgccg
ggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgg
gugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaagua
ccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgu
gaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagcggcgacgucggcuacccacccgacccgucuacacggaccaaggagu
cuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaag
gugggaucccgaggccaguccgccgagggcgcaccaccggcccgucucgc
ccggggagguggagcacgagcgcacguguuaggacccgaagcugguuccc
uccgaaguuucccucaggauagcuggcgcucucgcaguuuuauccggggu
aagaagcccggcucgagccgggcguggaaugcgagugccuagugggccac
uuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaag
gcgcccgaugccgacgcucacccagaaaagguguugguugauauagacag
caggacgguggccauggaagucggaauccgcuaaggaguguguaacaacu
caccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucggg
cccauacccggccgucgccggcagucgagaguggacggcgcggacgcuac
gccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgc
gggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaug
uuggaacaauguaggaccuacuauccagcgaaaccagccaagcuuggcuc
agccuggcuuguggcggccaagcgcgacgucgcuuuuugugugaagcaga
auucaccaaacugaugauguguuguugccaugguaauccugcucaguacg
agaggaaccgcagguucagacauuugguguaugugcuuggcugaggagcc
aauggggcgaagcuaccaucugugggauuaugacugaacgccucuaaguc
agaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccuc
ggauagccgguccccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcac
guucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucg
ggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagag
cccucgacacgguuugu
........................<<<<<<.............>>>>>.>
.........<<....>>..<<<<<<.....<<.....>>....>>>>>>.
.<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<
<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>
>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>
>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<
<<<<.>>>>>>..>>>..................................
<<....>>...............<<<<....>>>>...............
................<<<<<<<<..<<<......<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<...<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>.>>>>>>....>>>...>>>>>>>>..<<<<....>>>><<<<<<....
<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<
<<<<...<<<..<<........>>..>>>....>>>>>.<<<<<<<<<.<
<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...>.>>..<<<
<<<......<<<....>>>..<<.<<<<<<<..<<<.<<<<<<<<.>>>>
>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.
<<<<<...[[>>>>>.>>>>....<<<......>>>...<<<<<<<...<
<<(((.......<<<<<....<<<....<<<.<<<<<<<<<<.......<
<<<<.<<<...<<.........>>...>>>.........<<......>>.
..>>>>>...>>>>>>>>>>>>>.....>>>..)))......>>>>>..>
>>...>>>>>>><<<<<<.<<<..............<.>...........
>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<..
..>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<.....
.<<<<.....<<<<<.>>>>>..>>>>.>....>>.<<<<<<>>>>>><<
<<.]].......<<<<<<...<..>...>>>>>>......<<<<<.....
.>>>>>....>>>>......<<<<<<.<..<<<..<.<<<<<........
.........>>>>>.><<<<....<<<<...<.<..<<<<<<....>>>>
>>....>...>>>>>...>>>><<<<<...<<<<<...........>>>>
>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<...
.....<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>........
......>>>>..>>>>>>>>.<<<<<.<.............>....<<<<
<<<<<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>.>
>>>>.>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fkr Principles of human pre-60 S biogenesis.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		R16 R57 S76 S78 I98 H100 R119 L121 A122 R123 K130 E131 G134 T135 S138
Binding residue
(residue number reindexed from 1)		R7 R48 S67 S69 I89 H91 R110 L112 A113 R114 K121 E122 G125 T126 S129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fkr, PDBe:8fkr, PDBj:8fkr
PDBsum8fkr
PubMed37410842
UniProtP30050|RL12_HUMAN Large ribosomal subunit protein uL11 (Gene Name=RPL12)

[Back to BioLiP]