Structure of PDB 7qhk Chain BA Binding Site BS01
Receptor Information
>7qhk Chain BA (length=221) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
LPKSVDWRKKGYVTPVKNQKQCGSAWAFSATGALEGQMFRKTGKLVSLSE
QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY
RPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG
IYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGYV
KIAKDKNNHCGIATAASYPNV
Ligand information
>7qhk Chain PB (length=3) Species:
32630
(synthetic construct) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
QQE
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
7qhk
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.
Resolution
1.83 Å
Binding residue
(original residue number in PDB)
G244 A246 Q284 N287 G288 G289 F290 M291 D384 H385
Binding residue
(residue number reindexed from 1)
G23 A25 Q63 N66 G67 G68 F69 M70 D163 H164
Enzymatic activity
Enzyme Commision number
3.4.22.43
: cathepsin V.
Gene Ontology
Molecular Function
GO:0008234
cysteine-type peptidase activity
Biological Process
GO:0006508
proteolysis
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:7qhk
,
PDBe:7qhk
,
PDBj:7qhk
PDBsum
7qhk
PubMed
37095140
UniProt
O60911
|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)
[
Back to BioLiP
]