Structure of PDB 7d5s Chain B3 Binding Site BS01

Receptor Information
>7d5s Chain B3 (length=752) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YKGISLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHEI
TALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTS
TLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLA
SGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPPSLNLLSGGRDD
IINLWDFNMKKKCKLLKTLPVNQQVESCGFLKIIYTAGGDAIFQLIDSES
GSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNTI
QVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLASLPLDV
EIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYKFDIYAKYIGHSAA
VTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYI
NALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQY
LLATSSGDKTVKIWSSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIK
CLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEK
AKLQVEQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSR
QEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAKTHTIAQRTIRCILM
HHNIAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDK
LF
Ligand information
>7d5s Chain SA (length=859) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucacaa
auuagugacaauaaauaacgauacagggcccauucgggucuuguaauugg
aaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucu
ggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguug
uugcaggcucguaguugaacuuagggacggucgggggcaucaguauucaa
uugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaag
cauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucga
agaugaucagauaccgucguagucuuaacuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcucaacacggggaaacucaccagguccagacacaauaaggauugaca
uucuugauuuugugggugguggugcauugaugcccuuguucugggccacg
cgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuug
guaaucuugugaaacuccgucgugcuggggauauucaacgaggaauuccu
aguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguac
acaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggau
cugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaa
cuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaa
ccugcggaa
............................<<<<.<<<<<<...........
..................<<<<<<<.<<<<<....>>>>>.>>>.>>>>.
.....<<..<...........>..>>.........<<<<<<.......<<
<....>>>..................>>>>>>..>>>>>>>>>>......
...<..<.<<...<<<.......<<<<<<.<<...<<<<..<<..<<<<<
<.<...<<<......>>>......>.>>>>>>..>>.......<<....>
>...>>>>..>.>>>>.>>>...>>>...>>.>......<<<<<...<..
.<<<<.........>>>>...>>>>>>...>...................
.<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<
<<.......................<<.<....<<<<<........<...
..>......>>>>>......<<<........>>>...>.>>.......>>
>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>
>>............>>>>>>>.......................>>>>>>
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>.....
.......>>>>>..<<<..<<....<.<<<..<.<<<..<.<<......<
<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>..>
>>.>..>>>>....>>..>>>................<<<<<<<<<....
>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7d5s Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2)
Resolution4.6 Å
Binding residue
(original residue number in PDB)		K533 R619 N749 A750 K751
Binding residue
(residue number reindexed from 1)		K489 R561 N684 A685 K686
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d5s, PDBe:7d5s, PDBj:7d5s
PDBsum7d5s
PubMed
UniProtQ05946|UTP13_YEAST U3 small nucleolar RNA-associated protein 13 (Gene Name=UTP13)

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