Structure of PDB 6qx9 Chain B2 Binding Site BS01

Receptor Information
>6qx9 Chain B2 (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFK
RKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKV
RPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKKPGDL
SDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPE
SCSFGYHA
Ligand information
>6qx9 Chain 2 (length=94) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggcuguaguaucuguucuuaucaguuuaauaucugauagauu
uuuggagcaucgaccugguauugcaguaccuccaggaacggugc
...........................<<<<<.<....>.>>>>>.....
......<<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB6qx9 Mechanism of 5' splice site transfer for human spliceosome activation.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		H478 T481 W504 C505 R515
Binding residue
(residue number reindexed from 1)		H21 T24 W47 C48 R58
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qx9, PDBe:6qx9, PDBj:6qx9
PDBsum6qx9
PubMed30975767
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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