Structure of PDB 8qzs Chain B1 Binding Site BS01

Receptor Information
>8qzs Chain B1 (length=870) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERNRPLSDEELDAMFPEGYKVLNDQPSGNLPFLKPDDIQYFDKLLVDVDE
STLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQ
ILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLID
EDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAV
VASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLR
SLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKG
IRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEM
KKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLV
DTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADI
DHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICG
TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGE
EYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQEN
CIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYI
AKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMN
EYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVH
RQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGAL
EGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHY
PRIYNDDKNTYIRYELDYIL
Ligand information
>8qzs Chain 2 (length=98) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugaua
gauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc
...............................<<<<<.<....>.>>>>>.
..........<<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qzs Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution4.1 Å
Binding residue
(original residue number in PDB)		P509 E1064 H1069 P1224 P1257 A1258
Binding residue
(residue number reindexed from 1)		P75 E630 H635 P790 P823 A824
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qzs, PDBe:8qzs, PDBj:8qzs
PDBsum8qzs
PubMed38778104
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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