Structure of PDB 9iq9 Chain B Binding Site BS01

Receptor Information

>9iq9 Chain B (length=275) Species: 1914 (Streptomyces lavendulae)

MIDLIVSQGRVADRAAWMIEGAARTARALEERYGLKGHYVGEPAPHADDD
WSVALPQARETLVAVREAATESIKGDNLTVLVNNTCSVSLATLPVVAREH
PDAVVLYIDGHGDFNTPETTDTGYLGGMVLSGACGLWDSGHGAGLRPEQA
VLVGSRDIDEGERELIRKAGVRVIPPGEATAQAVLDAVKDAPVWIHIDWD
VLEPGSIPADYTVPDGMLPAQIRAVFEAIPAERLIGVELAELNAPADSER
AEQAVAVILDMVAPAFDAAAARPLE

Ligand information

• Ligand ID: CU1
• InChI: InChI=1S/Cu/q+1
• InChIKey: VMQMZMRVKUZKQL-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cu+]
• Formula: Cu
• Name: COPPER (I) ION
• PDB chain: 9iq9 Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9iq9 Copper inactivates DcsB by oxidation of the Cys86 to cysteine sulfinic aicd
• Resolution: 1.58 Å
• Binding residue (original residue number in PDB): D109 D113
• Binding residue (residue number reindexed from 1): D109 D113
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016787 hydrolase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0017000 antibiotic biosynthetic process
• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:9iq9, PDBe:9iq9, PDBj:9iq9
• PDBsum: 9iq9
• UniProt: D2Z025|DCSB_STRLA N(omega)-hydroxy-L-arginine amidinohydrolase (Gene Name=dcsB)