Structure of PDB 9foy Chain B Binding Site BS01

Receptor Information

>9foy Chain B (length=730) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLM
ADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEF
AYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSV
RVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLRIEPVDI
EQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSH
AKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPG
NDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRF
PNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVM
GRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLV
ITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKR
DAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQL
DVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAG
LIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILA
KPERQRGIVRDELAEIVDRHGDDRRTRIIA

Ligand information

>9foy Chain F (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtacctacggct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9foy Unraveling the Mycobacterium tuberculosis DNA gyrase-DNA-NBTI complex
Resolution	2.8 Å
Binding residue (original residue number in PDB)	K484 I486 N487 K490 R495 H539 R659 Y1028 R1128 Y1129 I1181 A1182 G1184 M1185
Binding residue (residue number reindexed from 1)	K54 I56 N57 K60 R65 H109 R229 Y258 R358 Y359 I411 A412 G414 M415

External links

PDB	RCSB:9foy, PDBe:9foy, PDBj:9foy
PDBsum	9foy
PubMed
UniProt	P9WG45\|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB); P9WG47\|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

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