Structure of PDB 9eoc Chain B Binding Site BS01

Receptor Information

>9eoc Chain B (length=485) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFT
ALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQ
EWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSK
LYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMF
GKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDL
EIVGFIDIADISSPPVLSRHLVLPIALNSANQIAGKIPNFCVLLHGSLKV
EGMVAIVQLGPEWHGMLYSQKKKSNLMMSLFEPGPEPLPWLGKMAQLGPI
SDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRN
ARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAH
PDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLH

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

9eoc Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9eoc Structural basis of the Integrator complex assembly and association with transcription factors.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	S10 S12 T86
Binding residue (residue number reindexed from 1)	S9 S11 T85
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0016180	snRNA processing
GO:0034243	regulation of transcription elongation by RNA polymerase II
GO:0034472	snRNA 3'-end processing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0032039	integrator complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:9eoc, PDBe:9eoc, PDBj:9eoc
PDBsum	9eoc
PubMed	38823386
UniProt	Q96SY0\|INT14_HUMAN Integrator complex subunit 14 (Gene Name=INTS14)

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