Structure of PDB 9ene Chain B Binding Site BS01

Receptor Information
>9ene Chain B (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTR
LVESRQTSNYHRCGRTAKGVSAFGQVISLDLRSQFPEEIRYTHILNRVLP
PDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGT
HDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFEV
TGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVE
FPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGL
DTVPSVIKQTSAFVMRTYKPLMDRPKCQG
Ligand information
>9ene Chain C (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcucuguggcgcaauggauagcgcauuggacuucuaauucaaagguugu
ggguucgagucccaccagagucg
<<<<<<<..<<<<........>>>>.<<<...........>>>.....<<
<<<.......>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB9ene The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		K52 R53 R101 F343
Binding residue
(residue number reindexed from 1)		K1 R2 R50 F274
Gene Ontology
Molecular Function
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0160154 tRNA pseudouridine(38/39) synthase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0031119 tRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:9ene, PDBe:9ene, PDBj:9ene
PDBsum9ene
PubMed38996458
UniProtQ9BZE2|PUS3_HUMAN tRNA pseudouridine(38/39) synthase (Gene Name=PUS3)

[Back to BioLiP]