Structure of PDB 9b35 Chain B Binding Site BS01

Receptor Information

>9b35 Chain B (length=444) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFS
KPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFV
IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA
LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI
EYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLT
SDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAG
LVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRR

Ligand information

Ligand ID

GLU

InChI

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChIKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES

Software	SMILES
ACDLabs 12.01	O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0	C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0	C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370	N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370	N[CH](CCC(O)=O)C(O)=O

Formula

C5 H9 N O4

Name

GLUTAMIC ACID

PDB chain

9b35 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9b35 Kainate receptor channel opening and gating mechanism
Resolution	3.4 Å
Binding residue (original residue number in PDB)	Y488 A518 R523 V685 G688 A689 T690 E738
Binding residue (residue number reindexed from 1)	Y58 A88 R93 V255 G258 A259 T260 E308
Annotation score	1

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:9b35, PDBe:9b35, PDBj:9b35
PDBsum	9b35
PubMed	38778115
UniProt	P42260\|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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