Structure of PDB 8xpn Chain B Binding Site BS01

Receptor Information
>8xpn Chain B (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQ
DDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQF
AGYSQQDSQELLLFLMDGLHEDLNKADNRKRYENNDHLDDFKAAEHAWQK
HKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCT
LQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKR
FSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGL
DGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8xpn Chain B Residue 1203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xpn The Crystal Structure of USP8 from Biortus.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C936 C939 C985 C988
Binding residue
(residue number reindexed from 1)		C173 C176 C222 C225
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:8xpn, PDBe:8xpn, PDBj:8xpn
PDBsum8xpn
PubMed
UniProtP40818|UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (Gene Name=USP8)

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