Structure of PDB 8x5f Chain B Binding Site BS01

Receptor Information
>8x5f Chain B (length=616) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRY
FAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKE
STGSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHD
KILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKA
MKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRS
IWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQ
HLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTK
TFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMI
CFYSLELKWDESKGLLPSGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRD
TKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYI
ISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVIL
RFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNN
CGEFRAVRDISVAPLN
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain8x5f Chain B Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8x5f structure of transport at 2.9 Angstroms resolution
Resolution2.96 Å
Binding residue
(original residue number in PDB)		N401 R570 W573
Binding residue
(residue number reindexed from 1)		N387 R551 W554
Annotation score1
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0001618 virus receptor activity
GO:0005315 phosphate transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
Biological Process
GO:0006817 phosphate ion transport
GO:0009615 response to virus
GO:0016036 cellular response to phosphate starvation
GO:0030643 intracellular phosphate ion homeostasis
GO:0035435 phosphate ion transmembrane transport
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8x5f, PDBe:8x5f, PDBj:8x5f
PDBsum8x5f
PubMed39169184
UniProtQ9UBH6|S53A1_HUMAN Solute carrier family 53 member 1 (Gene Name=XPR1)

[Back to BioLiP]