Structure of PDB 8x22 Chain B Binding Site BS01
Receptor Information
>8x22 Chain B (length=406) Species:
11676
(Human immunodeficiency virus 1) [
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IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPEN
PYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKK
SVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWK
GSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEE
LRQHLLRWGGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIY
AGIKVRQLSKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGVYYDP
SKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGAHTNDVKQLTEA
VQKIATESIVIWGKTPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTPP
LVKLWY
Ligand information
>8x22 Chain E (length=35) [
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tcgccccccttcggtgctttgcaccgaaggggggc
Receptor-Ligand Complex Structure
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PDB
8x22
Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.
Resolution
2.31 Å
Binding residue
(original residue number in PDB)
K22 W266 Q269 K395
Binding residue
(residue number reindexed from 1)
K18 W245 Q248 K374
External links
PDB
RCSB:8x22
,
PDBe:8x22
,
PDBj:8x22
PDBsum
8x22
PubMed
38977798
UniProt
P12497
|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)
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