Structure of PDB 8wow Chain B Binding Site BS01

Receptor Information
>8wow Chain B (length=338) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVLVTGGAGYIGSHTVLQLLEGGYSAVVVDNYDNSSAASLQRVKKLAGEN
GNRLSFHQVDLRDRPALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYN
NNIVGTVTLLEVMAQYGCKNLVFSSSATVYGWPKEVPCTEESPISATNPY
GRTKLFLEEICRDVHRSDSEWKIILLRYFNPVGAHPSGYIGEDPLGVPNN
LMPYVQQVAVGRRPHLTVFGTDYKTKDGTAVRDYIHVMDLADGHIAALRK
LDDLKISCEVYNLGTGNGTSVLEMVAAFEKASGKKIPLVMAGRRPGDAEV
VYASTEKAERELNWKAKNGIEEMCRDLWNWASNNPYGY
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain8wow Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wow Cytosolic UDP-L-arabinose synthesis by bifunctional UDP-glucose 4-epimerases in Arabidopsis.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		N183 N203 L204 L219 T220 V221 F222 R235 Y237 V274 R297 D300
Binding residue
(residue number reindexed from 1)		N180 N200 L201 L216 T217 V218 F219 R232 Y234 V271 R294 D297
Annotation score2
Enzymatic activity
Enzyme Commision number 5.1.3.2: UDP-glucose 4-epimerase.
Gene Ontology
Molecular Function
GO:0003978 UDP-glucose 4-epimerase activity
GO:0016853 isomerase activity
GO:1901149 salicylic acid binding
Biological Process
GO:0006012 galactose metabolic process
GO:0042546 cell wall biogenesis
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wow, PDBe:8wow, PDBj:8wow
PDBsum8wow
PubMed38678521
UniProtQ9T0A7|UGE2_ARATH UDP-glucose 4-epimerase 2 (Gene Name=UGE2)

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