Structure of PDB 8wny Chain B Binding Site BS01

Receptor Information
>8wny Chain B (length=456) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSL
CYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMT
FSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFT
GGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQG
SFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAM
SPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLC
FSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYV
SFINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVFS
FISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELC
FVVYPQ
Ligand information
Ligand IDDSN
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKeyMTCFGRXMJLQNBG-UWTATZPHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C([C@H](C(=O)O)N)O
CACTVS 3.341N[C@H](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
ACDLabs 10.04O=C(O)C(N)CO
FormulaC3 H7 N O3
NameD-SERINE
ChEMBLCHEMBL285123
DrugBankDB03929
ZINCZINC000000895342
PDB chain8wny Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wny Cryo-EM structure of the human Asc-1 transporter complex.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		I53 G55 F243 A244 S246 Y333
Binding residue
(residue number reindexed from 1)		I12 G14 F202 A203 S205 Y292
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006865 amino acid transport
GO:0015804 neutral amino acid transport
GO:0015816 glycine transport
GO:0015825 L-serine transport
GO:0042941 D-alanine transmembrane transport
GO:0042942 D-serine transmembrane transport
GO:0055085 transmembrane transport
GO:0060094 positive regulation of synaptic transmission, glycinergic
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903444 negative regulation of brown fat cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wny, PDBe:8wny, PDBj:8wny
PDBsum8wny
PubMed38589439
UniProtQ9NS82|AAA1_HUMAN Asc-type amino acid transporter 1 (Gene Name=SLC7A10)

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