Structure of PDB 8w6h Chain B Binding Site BS01

Receptor Information
>8w6h Chain B (length=461) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVT
ALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRI
ALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI
INAKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRC
LNFGSWFTFSFPAALIILLLSWIWLQWLFLIKQEYQKLGPIRYQEIVTLV
LFIIMALLWFSRGFATDSTVALLIGLLFFLIPAKTLTAFDYSPLITWKEF
QSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILIS
SLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAF
LLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMF
DLYTYPSWAPA
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain8w6h Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8w6h Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T141 S260
Binding residue
(residue number reindexed from 1)		T133 S182
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0015382 sodium:sulfate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w6h, PDBe:8w6h, PDBj:8w6h
PDBsum8w6h
PubMed38552027
UniProtQ9BZW2|S13A1_HUMAN Solute carrier family 13 member 1 (Gene Name=SLC13A1)

[Back to BioLiP]