Structure of PDB 8w6d Chain B Binding Site BS01

Receptor Information
>8w6d Chain B (length=529) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCT
EALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVE
HWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPI
AHAVLDQLHSSQAKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQ
INSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFG
IGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPG
FFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPG
KLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLT
PLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL
YVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVL
VIALAINSWGIPLFSLHSFPSWAQSNTTA
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain8w6d Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8w6d Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S136 I139 S140 N141 G239
Binding residue
(residue number reindexed from 1)		S135 I138 S139 N140 G190
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015138 fumarate transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015361 low-affinity sodium:dicarboxylate symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w6d, PDBe:8w6d, PDBj:8w6d
PDBsum8w6d
PubMed38552027
UniProtQ13183|S13A2_HUMAN Solute carrier family 13 member 2 (Gene Name=SLC13A2)

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