Structure of PDB 8vc1 Chain B Binding Site BS01

Receptor Information
>8vc1 Chain B (length=391) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CLVGGAHAFILKISSFCGLAPLRFEPRSQEYAVTISKGKCFYSYILVTFL
VICTIYGLVAEIGVGVEKSVRMSSRMSQVVSACDILVVAVTAGVGVYGAP
ARMRTMLSYMENIVAVDRELGRHHSAATERKLCALLLLILLSFTILLVDD
FCFYAMQAGKTGRQWEIVTNYAGFYFLWYIVMVLELQFAFTALSLRARLK
LFNEALNVTASQVCKPAFVMMKTADGVPCLQVPPCEAVGRLSRMRCTLCE
VTRHIADGYGLPLVIILMSTLLHLIVTPYFLIMEIIVSTHRLHFLVLQFL
WCTTHLIRMLVVVEPCHYTMREGKRTEDIVCRLMTLAPHGGVLSSKLEVL
SRLLMLQNISYSPLGMCTLDRPLIVTVLGAVTTYLVILIQF
Ligand information
Ligand ID9Z9
InChIInChI=1S/C34H56O5/c1-22-9-15-34(38-19-22)23(2)31-30(39-34)18-29-27-8-7-25-17-26(37-16-12-24(20-35-5)21-36-6)10-13-32(25,3)28(27)11-14-33(29,31)4/h7,22-24,26-31H,8-21H2,1-6H3/t22-,23+,26+,27-,28+,29+,30+,31+,32+,33+,34-/m1/s1
InChIKeyCEEBZAXXSRFQIC-GZSGZGDASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01CC34C2C(OC1(OCC(CC1)C)C2C)CC3C5C(CC4)C6(C)C(=CC5)CC(CC6)OCCC(COC)COC
OpenEye OEToolkits 2.0.6C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)OCCC(COC)COC)C)C)C)OC1
CACTVS 3.385COCC(CCO[CH]1CC[C]2(C)[CH]3CC[C]4(C)[CH](C[CH]5O[C]6(CC[CH](C)CO6)[CH](C)[CH]45)[CH]3CC=C2C1)COC
OpenEye OEToolkits 2.0.6CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OCCC(COC)COC)C)C)C)OC1
CACTVS 3.385COCC(CCO[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](C[C@@H]5O[C@]6(CC[C@@H](C)CO6)[C@@H](C)[C@H]45)[C@@H]3CC=C2C1)COC
FormulaC34 H56 O5
Name(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
ChEMBL
DrugBank
ZINC
PDB chain8vc1 Chain B Residue 508 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8vc1 Structure of an insect gustatory receptor.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		V95 L324 L325 I328 Y332 L441
Binding residue
(residue number reindexed from 1)		V80 L271 L272 I275 Y279 L388
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0170021 ionotropic taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007635 chemosensory behavior
GO:0008049 male courtship behavior
GO:0050909 sensory perception of taste
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vc1, PDBe:8vc1, PDBj:8vc1
PDBsum8vc1
PubMed38187590
UniProtB3GTD7

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