Structure of PDB 8v84 Chain B Binding Site BS01

Receptor Information
>8v84 Chain B (length=331) Species: 1390929 (Saccharomyces cerevisiae BY4741-AV16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDLD
RPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLS
DEVKRRFYKNWYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVL
VHTQIRKTPLAQKKAHLAEIQLNGGSISEKVDWAREHFEKTVAVDSVFEQ
NEMIDAIAVTKGHGGYHSRTSINHKIYRVGKGDDEANGATSFDRTKKTIT
PMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSL
KWIDTASKFGKGRFQTPAEKHAFMGTLKKDL
Ligand information
>8v84 Chain 1 (length=1970) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaacaauaagcggaggaa
aagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagc
ucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagg
gcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucaua
gagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccu
ucgaagagucgaguuguaugcagcucuaagugggugguaaauuccaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaa
gaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaa
agggaagggcauuugaucagacaugguguuuugugcccucugcuccuugu
ggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcag
gauaaauccauaggaauguagcuugccucgguaaguauuauagccugugg
gaauacugccagcugggacugaggacugcgacguaagucaaggaugcugg
cauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaac
gucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaac
guagguuggggccucgcaagaggugcacaaucgaccgauccugaggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaaggguauaggggcaagacaccaucuaguagcugguuccugccgaagu
uucccucaggauagcagaagcucguaucaguuuuagaaugaagagcuuuu
agugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacg
uagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguu
aguucaucuagacagccggacgguggccauggaagucggaauccgcuaag
gaguguguaacaacucaccggccgaaugaacuagcccugaaaauggaugg
cgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccu
gacgaguaggcaggcguggaggucagugacgaagccuagaccguaagguc
gggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaa
augaggaacagccucuaguugauagaauaauguagauauaucuacuaucu
agcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaaga
agacccuguugagcuugacucuaguuugacauugugaagagacauagagg
guguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuau
aguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacu
ggcuuguggcagucaagcguucauagcgacauugcuugauucuauaccga
agcagaauucgguaagccgucgugagacaggccuacugaguuaccgcaau
aguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuu
ugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuau
ggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcucca
cacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagca
ggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaa
uugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgg
gguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaa
gccuuuguugucugauuugu
..........................<<<<<<........>>>>>.>...
......<<....>>..<<<<<......<<.....>>.....>>>>>..<<
<...........<<.<<<<<<...>>>>>>.>>.............<<<<
<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.....
..<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>
>>........<<<<<<<..>>>>>>>.....<<<<<<......>>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....
>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<
.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>
.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>
>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<
<.<<<<<<..<<<...<<<<.....>>>>...>>>...............
...<<<<<..<<<<<....>>>>>...>>>>>....<.<<<.......>>
>..>........>>>>>>.>>>>>>..<<.<...<<<<<<...<<<<<<<
<...>>>>>>>>..<.....>>>>>>>......>.>>..<<<<<<....<
.<<<....>>>.><<<<<<<<<<...<<<.<<<..>>>>>>.>>>>>>>>
.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<
<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.....
....<<......>>...>>>>>...>>>>>>>>>>>>>..........))
).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>
>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>
>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<
..<<.........>>...>>>><<<<...<.<<<<<<..>>>>>>>.>>>
>>>....>>...<<<<<<........>>>>>>....<<<<..<<<.....
...<<<<<<.<<<<<<..<<<<..<<<<<<....<..<<<<<<<<<<<.<
<..........<<<<..<<<..>>>............>>>>..>>>>>>>
.>>>>>>..>.....>>>>>>...>>>>..>>>>>.>.>>>>>>......
........<<<<<...<<.......>>...>>>>>.........<<<<<<
<......>>>>>>>....<<<....>>>...>>>.>>>>.<<<<<<<..<
<<<.<.<<<<<<...............>>>>>>.><<<<<..<.<.<...
.<<<<<<<<<<....>>>>>..>>>>>...>.>>..>>>>>.<<<<...<
<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<<..
<......<<..........<<<<<<.....>>>>>>......>>......
.<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...
.........>.>>>..<<<<<<.<.............>.....<<<<<<<
<<.<<<....<<<<.....<.<........>.>....>>>>...>>>...
.>>>>.>>>>>..>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8v84 The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
H13 L14 G15 P18 K20 R21 R26 R28 K30 A31 K50 M53 T55 R62 G64 S65 Y92 T95 R97 L99 R100 L102 T104 W106 R116 F118 Y119 K120 N121 Y123 K124 S125 K126 K128 F130 K132 Y133 R150 Y154 R159 Q173 K174 K175 E180 T221 K222 G223 H224 G225 Y272 S274 R275 N279 M308 G309 H313 G315 C327 P329 G330 N331 K333 R334 L342 Y343 R348 S363 F365 K367 K376 M380 L383 K384
Binding residue
(residue number reindexed from 1)
H2 L3 G4 P7 K9 R10 R15 R17 K19 A20 K39 M42 T44 R51 G53 S54 Y81 T84 R86 L88 R89 L91 T93 W95 R105 F107 Y108 K109 N110 Y112 K113 S114 K115 K117 F119 K121 Y122 R139 Y143 R148 Q162 K163 K164 E169 T210 K211 G212 H213 G214 Y216 S218 R219 N223 M252 G253 H257 G259 C271 P273 G274 N275 K277 R278 L286 Y287 R292 S307 F309 K311 K320 M324 L327 K328
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006414 translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8v84, PDBe:8v84, PDBj:8v84
PDBsum8v84
PubMed38632236
UniProtP14126|RL3_YEAST Large ribosomal subunit protein uL3 (Gene Name=RPL3)

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