Structure of PDB 8v6o Chain B Binding Site BS01

Receptor Information
>8v6o Chain B (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASD
TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQ
TALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPL
ALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDF
VKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIK
EKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNR
HEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREE
EAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSI
LSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYT
RGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDN
KDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTF
VLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFR
MGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPV
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain8v6o Chain B Residue 907 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v6o TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Resolution2.83 Å
Binding residue
(original residue number in PDB)		H417 L420 H426 L429 H430 R693
Binding residue
(residue number reindexed from 1)		H301 L304 H310 L313 H314 R577
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v6o, PDBe:8v6o, PDBj:8v6o
PDBsum8v6o
PubMed38691614
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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