Structure of PDB 8uoz Chain B Binding Site BS01

Receptor Information
>8uoz Chain B (length=110) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNPYIYLGGAILAQVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQT
LAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLI
INLLSRSTPH
Ligand information
Ligand IDP4P
InChIInChI=1S/C24H20P/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24/h1-20H/q+1
InChIKeyUSFPINLPPFWTJW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		c1ccc(cc1)[P+](c2ccccc2)(c3ccccc3)c4ccccc4
ACDLabs 10.04c1c(cccc1)[P+](c2ccccc2)(c3ccccc3)c4ccccc4
FormulaC24 H20 P
NameTETRAPHENYLPHOSPHONIUM
ChEMBLCHEMBL1182234
DrugBank
ZINCZINC000008234386
PDB chain8uoz Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8uoz Molecular Basis of Drug Recognition by EmrE
ResolutionN/A
Binding residue
(original residue number in PDB)		S64 I68
Binding residue
(residue number reindexed from 1)		S64 I68
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015199 amino-acid betaine transmembrane transporter activity
GO:0015220 choline transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006970 response to osmotic stress
GO:0006974 DNA damage response
GO:0009410 response to xenobiotic stimulus
GO:0015871 choline transport
GO:0031460 glycine betaine transport
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
GO:0071466 cellular response to xenobiotic stimulus
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1990207 EmrE multidrug transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uoz, PDBe:8uoz, PDBj:8uoz
PDBsum8uoz
PubMed38806470
UniProtP23895|EMRE_ECOLI Multidrug transporter EmrE (Gene Name=emrE)

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