Structure of PDB 8tpr Chain B Binding Site BS01

Receptor Information
>8tpr Chain B (length=592) Species: 660122 (Fusarium vanettenii 77-13-4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFGVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESLL
VFVKVASPDLFAKQVYRARLGDWLHGVRVSAPAQALQEPVVEAERLRLIY
LMITKPHNEGGAGVTPTNAKWKHVESIFPLHSHSFNKEWIKKWSSKYTLE
QTDIDNIRDKFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLY
ALLCGLWSVVFFEYWKKQEVDLAVQWGVRGVSSIQQSRPEFEWEHEAEDP
ITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVY
GKQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQK
QFVLNFMTSYMALFFTAFVYIPFGHILHPFLNFWRAINPARISNQMFYFT
VTPQIVNFATEVVVEEAEFLQRVREECTLEEYDVSGDYREMVMQFGYVAM
FSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALS
FLSWLGSITSSAIVYLCSNKAWGLLLSILFAEHFYLVVQLAVRFVLSKLD
SPGLQKERKERFQTKTPEEMFWQRQRGMQETIEIGRRMIEQQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8tpr Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8tpr Structural basis of closed groove scrambling by a TMEM16 protein.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		E452 D503 E506 E535 D539
Binding residue
(residue number reindexed from 1)		E411 D437 E440 E469 D473
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tpr, PDBe:8tpr, PDBj:8tpr
PDBsum8tpr
PubMed38684930
UniProtC7Z7K1

[Back to BioLiP]