Structure of PDB 8tg9 Chain B Binding Site BS01

Receptor Information
>8tg9 Chain B (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVL
GSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHW
RVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQA
LMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLL
RTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQG
GQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHL
AYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQ
RMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQE
LVAVSGRKLNWPLGYPPPDIPKCGF
Ligand information
>8tg9 Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CFGGRMDRIGAQSGLGCNSFR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tg9 Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution3.08 Å
Binding residue
(original residue number in PDB)		Y88 R95 H185 E187 H195 R198
Binding residue
(residue number reindexed from 1)		Y88 R95 H185 E187 H195 R198
External links
PDB RCSB:8tg9, PDBe:8tg9, PDBj:8tg9
PDBsum8tg9
PubMed
UniProtP16066|ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (Gene Name=NPR1)

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